FCN1

Gene Symbol	FCN1
Entrez Gene	2219
Alt Symbol	FCNM
Species	Human
Gene Type	protein-coding
Description	ficolin (collagen/fibrinogen domain containing) 1
Other Description	M-ficolin|collagen/fibrinogen domain-containing protein 1|ficolin (collagen/fibrinogen domain-containing) 1|ficolin-1|ficolin-A|ficolin-alpha
Swissprots	Q5VYV5 Q92596 O00602
Accessions	BAA09707 CBX51283 EAW88137 EAW88138 EAW88139 EAW88140 O00602 AK314867 BAG37382 BC020635 AAH20635 BG482630 CR749452 CAH18289 D83920 BAA12120 DQ891426 ABM82352 DQ894436 ABM85362 NM_002003 NP_001994
Function	Extracellular lectin functioning as a pattern- recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6- linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. {ECO:0000269|PubMed:20032467, ECO:0000269|PubMed:21037097}.
Subcellular Location	Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Found on the monocyte and granulocyte surface.
Tissue Specificity	Peripheral blood leukocytes, monocytes and granulocytes. Also detected in spleen, lung, and thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes. {ECO:0000269|PubMed:20400674}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-FCN1-cDNA-Clone - DC04926 from Abgent, a WuXi AppTec company Prices $440.10 Sizes 10 µg Species Human Accession BC020635

FCN1 - MBS1268659 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC020635

Human FCN1 ORF clone - CDCL107671 from Creative Biomart Species Human Accession NM_002003

Human FCN1 ORF clone - CDCL107672 from Creative Biomart Species Human Accession NM_002003

Human FCN1 ORF Clone(NM_002003.3) - CDCL163368 from Creative Biomart Species Human Accession NM_002003.3

Human FCN1/FCNA Gene ORF cDNA clone in cloning vector - HG10930-M from Sino Biological Species Human

Human FCN1/FCNA Gene ORF cDNA clone expression plasmid, C-His tag - HG10930-CH from Sino Biological Species Human

Human FCN1/FCNA Gene ORF cDNA clone expression plasmid - HG10930-UT from Sino Biological Species Human

Human FCN1/FCNA Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10930-M-F from Sino Biological Species Human

Human FCN1/FCNA Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10930-ACG from Sino Biological Species Human

Human FCN1/FCNA Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10930-NF from Sino Biological Species Human

Human FCN1/FCNA Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10930-NM from Sino Biological Species Human

Human FCN1/FCNA Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10930-CF from Sino Biological Species Human

Human FCN1/FCNA Gene ORF cDNA clone expression plasmid, C-HA tag - HG10930-CY from Sino Biological Species Human

Human FCN1 natural ORF mammalian expression plasmid, C-Myc tag - HG10930-CM from Sino Biological Species Human Accession NM_002003.2

Human FCN1 Gene cDNA Clone (full-length ORF Clone) expression ready, untagged - HG10930-M-N from Sino Biological Species Human Accession NM_002003.2

Human FCN1/FCNA Gene ORF cDNA clone expression plasmid, N-His tag - HG10930-NH from Sino Biological Species Human

Human FCN1/FCNA Gene ORF cDNA clone expression plasmid, N-HA tag - HG10930-NY from Sino Biological Species Human

Human FCN1 ORF Clone (BC020635) - CDCS410555 from Creative biogene Species Human Accession O00602

Human FCN1/FCNA Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10930-ACR from Sino Biological Species Human

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