| Gene Symbol |
FCN1
|
| Entrez Gene |
2219
|
| Alt Symbol |
FCNM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ficolin (collagen/fibrinogen domain containing) 1
|
| Other Description |
M-ficolin|collagen/fibrinogen domain-containing protein 1|ficolin (collagen/fibrinogen domain-containing) 1|ficolin-1|ficolin-A|ficolin-alpha
|
| Swissprots |
Q5VYV5 Q92596 O00602
|
| Accessions |
BAA09707 CBX51283 EAW88137 EAW88138 EAW88139 EAW88140 O00602 AK314867 BAG37382 BC020635 AAH20635 BG482630 CR749452 CAH18289 D83920 BAA12120 DQ891426 ABM82352 DQ894436 ABM85362 NM_002003 NP_001994
|
| Function |
Extracellular lectin functioning as a pattern- recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6- linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. {ECO:0000269|PubMed:20032467, ECO:0000269|PubMed:21037097}.
|
| Subcellular Location |
Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Found on the monocyte and granulocyte surface.
|
| Tissue Specificity |
Peripheral blood leukocytes, monocytes and granulocytes. Also detected in spleen, lung, and thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes. {ECO:0000269|PubMed:20400674}.
|
