COPS8

Gene Symbol COPS8
Entrez Gene 10920
Alt Symbol COP9, CSN8, SGN8
Species Human
Gene Type protein-coding
Description COP9 signalosome subunit 8
Other Description COP9 constitutive photomorphogenic homolog subunit 8|COP9 homolog|COP9 signalosome complex subunit 8|JAB1-containing signalosome subunit 8|hCOP9|signalosome subunit 8
Swissprots Q53QS9 A8K1H6 Q99627
Accessions AAY14978 EAW71097 EAW71098 EAW71099 EAW71100 Q99627 AA004869 AI077560 AI690743 AK289891 BAF82580 AK294078 BAG57420 AK308962 AK313437 BAG36228 AL038738 BC003090 AAH03090 BC036499 AAH36499 BC080617 AAH80617 BF979628 BG721393 BQ716842 CR456994 CAG33275 HQ448684 ADQ33162 U51205 AAB38529 NM_006710 NP_006701 NM_198189 NP_937832
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.

CSN8 (C-14) - sc-47976 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CSN8 (C-14): sc-47976. Western blot analysis of CSN8 expression in HeLa (A), NIH/3T3 (B), MCF7 (C), 3T3-L1 (D) and F9 (E) whole cell lysates and mouse embryo tissue extract (F).

CSN8 (F-8) - sc-393482 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CSN8 (F-8): sc-393482. Western blot analysis of CSN8 expression in HeLa (A), T24 (B), SK-MEL-24 (C) and MCF7 (D) whole cell lysates and human liver tissue extract (E).

CSN8 (K-18) - sc-47980 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CSN8 (FL-209) - sc-366850 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CSN8 (FL-209): sc-366850. Western blot analysis of CSN8 expression in non-transfected 293T: sc-117752 (A), mouse CSN8 transfected 293T: sc-119487 (B), HeLa (C), NIH/3T3 (D) and F9 (E) whole cell lysates and mouse embryo tissue extract (F).

CSN8 (K-16) - sc-47979 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CSN8 (K-16): sc-47979. Western blot analysis of CSN8 expression in HeLa (A), NIH/3T3 (B) and F9 (C) whole cell lysates and mouse embryo tissue extract (D).

Anti-COPS8 antibody - ab77300 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-COPS8 antibody (ab77300) at 1 µg/mlLane 1 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 2 : SHSY-5Y (Human neuroblastoma cell line) Whole Cell LysateLane 3 : Saos 2 (Human epithelial-like osteosarcoma cell line) Whole Cell LysateLane 4 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-COPS8 antibody - ab106560 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-COPS8 antibody (ab106560) at 2 µg/ml + Human liver lysate at 15 µg

Anti-COPS8 antibody - ab77462 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-COPS8 antibody (ab77462) at 1/500 dilution + immunogen at 0.2 µgSecondaryGoat anti-mouse IgG (H&L)-HRP conjugate at 1/5000 dilution

Anti-COPS8 antibody - ab68531 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-COPS8 antibody (ab68531) at 1/500 dilution + human kidney lysate at 25 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-COPS8 antibody [EPR5139] - ab124779 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5139
ab124779, at 1/100, staining COPS8 in formalin fixed paraffin embedded Human brain tissue using immunohistochemistry.

Anti-COPS8 / COP9 Antibody (aa1-30, AP) - LS-C213395 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPS8 / COP9 Antibody (aa1-30, APC) - LS-C213396 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPS8 / COP9 Antibody (aa1-30, Biotin) - LS-C213397 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPS8 / COP9 Antibody (aa1-30, Azide-free, HRP) - LS-C213398 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPS8 / COP9 Antibody (aa1-30, FITC) - LS-C213399 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPS8 / COP9 Antibody (aa1-30, PE) - LS-C213400 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPS8 / COP9 Antibody (C-Terminus) - LS-C116463 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
COPS8 antibody LS-C116463 Western blot of HepG2 cell lysate.

Anti-COPS8 / COP9 Antibody - LS-C307815 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-COPS8 / COP9 Antibody - LS-C307816 from LifeSpan Bioscience

Host Mouse
Clonality Polyclonal

Anti-COPS8 / COP9 Antibody (aa1-30) - LS-C320525 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPS8 / COP9 Antibody (aa1-30) - LS-C166946 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
COPS8 Antibody western blot of Ramos cell line lysates (35 ug/lane). The COPS8 antibody detected the COPS8 protein (arrow).

Anti-COPS8 / COP9 Antibody (C-Terminus, clone EPR5139) - LS-C138441 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal
Clone [EPR5139]
IHC of paraffin-embedded human brain tissue using anti-COPS8 antibody.

Anti-COPS8 / COP9 Antibody (C-Terminus) IHC-plus™ - LS-B4592 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-COPS8 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4592 concentration 5 ug/ml.

COP9 Antibody - NBP1-85435 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

COPS8 Antibody - H00010920-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: COPS8 Antibody [H00010920-B01] - COPS8 MaxPab polyclonal antibody (B01), Lot # 07325-WULz. Western Blot analysis of COPS8 expression in rat brain.
Search more