COPS8

Gene Symbol	COPS8
Entrez Gene	10920
Alt Symbol	COP9, CSN8, SGN8
Species	Human
Gene Type	protein-coding
Description	COP9 signalosome subunit 8
Other Description	COP9 constitutive photomorphogenic homolog subunit 8|COP9 homolog|COP9 signalosome complex subunit 8|JAB1-containing signalosome subunit 8|hCOP9|signalosome subunit 8
Swissprots	Q53QS9 A8K1H6 Q99627
Accessions	AAY14978 EAW71097 EAW71098 EAW71099 EAW71100 Q99627 AA004869 AI077560 AI690743 AK289891 BAF82580 AK294078 BAG57420 AK308962 AK313437 BAG36228 AL038738 BC003090 AAH03090 BC036499 AAH36499 BC080617 AAH80617 BF979628 BG721393 BQ716842 CR456994 CAG33275 HQ448684 ADQ33162 U51205 AAB38529 NM_006710 NP_006701 NM_198189 NP_937832
Function	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

COPS8 peptide - ab93795 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human COPS8 full length protein - ab113601 from Abcam Category Protein Source E. coli Species Human

COPS8 / COP9 Antibody Blocking Peptide - LS-E3771 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COPS8 / COP9 Antibody Blocking Peptide - LS-E18770 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COPS8 / COP9 Antibody Blocking Peptide - LS-E30497 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

COPS8 Recombinant Protein - H00010920-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

COPS8 Blocking Peptide - NBP1-76373PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant Human COPS8 Protein - NBP1-72515 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

COPS8-Antibody-N-term-Blocking-Peptide - BP14987a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

COPS8 Peptide - GTX85400-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

Human COPS8 protein - orb168146 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

COPS8 protein (His tag) - 80R-2029 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

COPS8 (1-209, His-tag) - AR50101PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

COPS8 (1-209, His-tag) - AR50101PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

COPS8 - H00010920-P01-02 from Acris Antibodies Category Protein Prices $300.00 Sizes 2 µg Source in vitro transl. Species Human

COPS8 Control Peptide - AP30245CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

COPS8, 1-209aa, Human, His tag, E.coli - 01-P1276 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

CSN8 Peptide - 4601P from ProSci Category Peptide Species Human

COPS8 fusion protein - ag0143 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

COPS8 Human - PRPS-990 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human COP9 Constitutive Photomorphogenic 8 Protein - BP001540-PRO-983 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

COPS8, 1-209aa, Recombinant Protein - GWB-P0762H from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human COPS8, His-tagged - COPS8-26339TH from Creative Biomart Category Protein Source E. coli

Recombinant Human COPS8, His-tagged - COPS8-26341TH from Creative Biomart Category Protein Source E. coli

Recombinant Human COP9 Signalosome Complex Subunit 8, His-tagged - COPS8-4734H from Creative Biomart Category Protein

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