COPS8

Gene Symbol COPS8
Entrez Gene 10920
Alt Symbol COP9, CSN8, SGN8
Species Human
Gene Type protein-coding
Description COP9 signalosome subunit 8
Other Description COP9 constitutive photomorphogenic homolog subunit 8|COP9 homolog|COP9 signalosome complex subunit 8|JAB1-containing signalosome subunit 8|hCOP9|signalosome subunit 8
Swissprots Q53QS9 A8K1H6 Q99627
Accessions AAY14978 EAW71097 EAW71098 EAW71099 EAW71100 Q99627 AA004869 AI077560 AI690743 AK289891 BAF82580 AK294078 BAG57420 AK308962 AK313437 BAG36228 AL038738 BC003090 AAH03090 BC036499 AAH36499 BC080617 AAH80617 BF979628 BG721393 BQ716842 CR456994 CAG33275 HQ448684 ADQ33162 U51205 AAB38529 NM_006710 NP_006701 NM_198189 NP_937832
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.

COPS8-Over-expression-Lysate - LY13632a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag COPS8 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the COPS8 gene

COPS8 293T Cell Transient Overexpression Lysate(Denatured) - H00010920-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

COPS8 293T Cell Transient Overexpression Lysate(Denatured) - H00010920-T02 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

COPS8 overexpression lysate - LY404971 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

COPS8 293 Cell Lysate - 403496 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

COPS8 293 Cell Lysate - 407692 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

COPS8 Overexpression Lysate (Denatured) - H00010920-T02 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl
Species Human
COPS8 transfected lysate.

COPS8 Overexpression Lysate (Denatured) - H00010920-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
COPS8 transfected lysate

COPS8 Overexpression Lysate (Native) - NBL1-09386 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

COPS8 Overexpression Lysate (Native) - NBL1-09385 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: COPS8 Overexpression Lysate (Adult Normal) [NBL1-09385] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for COPS8.

COPS8 Over-expression Lysate Product - GWB-56F3F7 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

COPS8 Over-expression Lysate Product - GWB-3D012D from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human COPS8 Knockdown Stable Cell Line - CSC-DC003506 from Creative biogene

Category Cell Line
Species Human
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