| Gene Symbol |
GRB14
|
| Entrez Gene |
2888
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
growth factor receptor-bound protein 14
|
| Other Description |
GRB14 adapter protein
|
| Swissprots |
Q14449 B7Z7F9 Q7Z6I1
|
| Accessions |
AAY14768 AAY24176 EAX11342 EAX11343 Q14449 AK301961 BAH13595 AK302129 BAH13632 AK307744 AK309590 AK313153 BAG35971 BC053559 AAH53559 CN266581 DB560753 DC359097 EU832411 ACE86896 L76687 AAC15861 XM_006712457 XP_006712520 XM_011511022 XP_011509324 XR_427085 NM_001303422 NP_001290351 NM_004490 NP_004481
|
| Function |
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}.
|
| Subcellular Location |
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Upon insulin stimulation, translocates to the plasma membrane.
|
| Tissue Specificity |
Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.
|