GRB14

Gene Symbol GRB14
Entrez Gene 2888
Alt Symbol -
Species Human
Gene Type protein-coding
Description growth factor receptor-bound protein 14
Other Description GRB14 adapter protein
Swissprots Q14449 B7Z7F9 Q7Z6I1
Accessions AAY14768 AAY24176 EAX11342 EAX11343 Q14449 AK301961 BAH13595 AK302129 BAH13632 AK307744 AK309590 AK313153 BAG35971 BC053559 AAH53559 CN266581 DB560753 DC359097 EU832411 ACE86896 L76687 AAC15861 XM_006712457 XP_006712520 XM_011511022 XP_011509324 XR_427085 NM_001303422 NP_001290351 NM_004490 NP_004481
Function Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}.
Subcellular Location Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Upon insulin stimulation, translocates to the plasma membrane.
Tissue Specificity Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.

GRB14 CRISPR/Cas9 KO Plasmid (h) - sc-405224 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRB14 HDR Plasmid (h) - sc-405224-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRB14 Double Nickase Plasmid (h) - sc-405224-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRB14 Double Nickase Plasmid (h2) - sc-405224-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRB14 CRISPR Activation Plasmid (h) - sc-405224-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRB14 CRISPR Activation Plasmid (h2) - sc-405224-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRB14 Lentiviral Activation Particles (h) - sc-405224-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRB14 Lentiviral Activation Particles (h2) - sc-405224-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GRB14 siRNA (h) - sc-40963 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GRB14 shRNA Plasmid (h) - sc-40963-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GRB14 shRNA (h) Lentiviral Particles - sc-40963-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU030091 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9664 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9664 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

GRB14 siRNA (Human) - CRH1942 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GRB14 - MBS8200546 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GRB14 (NM_004490.2) - SHH307578 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human GRB14(NM_004490.2) - SHH103241 from Creative biogene

Category siRNA
Species Reactivities Human

Human GRB14 siRNA - orb262444 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GRB14 shRNA Plasmid (Human) - CHH1942 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GRB14 miRNA 3'UTR clone - MiUTR1H-04251 from Creative biogene

Species Reactivities Human
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