GRB14

Gene Symbol GRB14
Entrez Gene 2888
Alt Symbol -
Species Human
Gene Type protein-coding
Description growth factor receptor-bound protein 14
Other Description GRB14 adapter protein
Swissprots Q14449 B7Z7F9 Q7Z6I1
Accessions AAY14768 AAY24176 EAX11342 EAX11343 Q14449 AK301961 BAH13595 AK302129 BAH13632 AK307744 AK309590 AK313153 BAG35971 BC053559 AAH53559 CN266581 DB560753 DC359097 EU832411 ACE86896 L76687 AAC15861 XM_006712457 XP_006712520 XM_011511022 XP_011509324 XR_427085 NM_001303422 NP_001290351 NM_004490 NP_004481
Function Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}.
Subcellular Location Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Upon insulin stimulation, translocates to the plasma membrane.
Tissue Specificity Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.

GRB14 (H-80) - sc-20755 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GRB14 (H-80): sc-20755. Western blot analysis of GRB14 expression in Hep G2 whole cell lysate.

GRB14 (N-19) - sc-6103 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-GRB 14 antibody - ab74961 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GRB 14 antibody (ab74961) at 1/500 dilutionLane 1 : extracts from COLO cells Lane 2 : extracts from HUVEC cells Lane 3 : extracts from MCF-7 cells Lane 4 : extracts from HUVEC cells with immunizing peptide at 5 µgLysates/proteins at 15 µg per lane.

Anti-GRB14 Antibody (N-Terminus) - LS-C7298 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-GRB14 Antibody (aa251-300) - LS-C170403 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-GRB14 Antibody (aa81-130) - LS-C120011 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HUVEC/COLO/MCF-7 cells, using GRB14 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-GRB14 Antibody (aa87-117) - LS-C166662 from LifeSpan Bioscience

Prices $250.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of GRB14 Antibody (N-term) in mouse liver tissue lysates (35 ug/lane). GRB14 (arrow) was detected using the purified Pab.

Anti-GRB14 Antibody (aa75-249) - LS-C178978 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GRB14 Antibody (Asp123) - LS-C177377 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of GRB14 (D123) pAb in paraffin-embedded human kidney tissue.

GRB 14 Antibody - NBP1-00863 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: GRB 14 Antibody [NBP1-00863] - Western blot (WB) analysis of GRB 14 (D123) antibody in extracts from HUVEC cells

GRB 14 Antibody - NBP2-38230 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: GRB 14 Antibody [NBP2-38230] - Staining of human testis shows moderate cytoplasmic positivity in cells in seminiferus ducts, Leydig cells were strongly stained.

GRB 14 Antibody - NBP1-68527 from Novus Biologicals

Prices $229.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: GRB 14 Antibody [NBP1-68527] - Analysis of extracts from HuvEc/COLO/MCF-7 cells, using GRB 14 Antibody. The lane on the right is treated with the synthesized peptide.

GRB 14 Polyclonal Antibody - bs-13641R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded human kidney labeled with Anti-GRB 14 Polyclonal Antibody, Unconjugated (bs-13641R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

GRB 14 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13641R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GRB 14 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13641R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GRB 14 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-13641R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GRB 14 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-13641R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GRB 14 Polyclonal Antibody, Cy3 Conjugated - bs-13641R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GRB 14 Polyclonal Antibody, Cy5 Conjugated - bs-13641R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GRB 14 Polyclonal Antibody, Cy5.5 Conjugated - bs-13641R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GRB 14 Polyclonal Antibody, Cy7 Conjugated - bs-13641R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GRB 14 Polyclonal Antibody, FITC Conjugated - bs-13641R-FITC from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GRB 14 Polyclonal Antibody, Biotin Conjugated - bs-13641R-Biotin from Bioss

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GRB 14 Polyclonal Antibody, HRP Conjugated - bs-13641R-HRP from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GRB14 antibody produced in rabbit - SAB2701027 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-GRB14: <B>Cat. No. SAB2701027</B>: Immunohistochemical analysis of paraffin-embedded NCIN87 xenograft, using GRB14 antibody at 1:500 dilution.
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