GRB14

Gene Symbol	GRB14
Entrez Gene	2888
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	growth factor receptor-bound protein 14
Other Description	GRB14 adapter protein
Swissprots	Q14449 B7Z7F9 Q7Z6I1
Accessions	AAY14768 AAY24176 EAX11342 EAX11343 Q14449 AK301961 BAH13595 AK302129 BAH13632 AK307744 AK309590 AK313153 BAG35971 BC053559 AAH53559 CN266581 DB560753 DC359097 EU832411 ACE86896 L76687 AAC15861 XM_006712457 XP_006712520 XM_011511022 XP_011509324 XR_427085 NM_001303422 NP_001290351 NM_004490 NP_004481
Function	Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}.
Subcellular Location	Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Upon insulin stimulation, translocates to the plasma membrane.
Tissue Specificity	Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GRB14 Gene cDNA Clone - orb143453 from Biorbyt Prices $366.00 Sizes 10 μg Species Human

GRB14 - MBS1269957 from MyBioSource Species Human Accession BC053559

Human GRB14 Gene cDNA clone plasmid - HG14084-G from Sino Biological Species Human

Human GRB14 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG14084-UT from Sino Biological Species Human Accession BC053559

Human GRB14 natural ORF mammalian expression plasmid, C-OFPSpark tag - HG14084-ACR from Sino Biological Species Human Accession BC053559

Human GRB14 natural ORF mammalian expression plasmid, N-OFPSpark tag - HG14084-ANR from Sino Biological Species Human Accession BC053559

Human GRB14 Gene cDNA Clone (full-length ORF Clone), expression ready, C-HA-tagged - HG14084-CY from Sino Biological Species Human Accession BC053559

Human GRB14 natural ORF mammalian expression plasmid, C-GFPSpark tag - HG14084-ACG from Sino Biological Species Human Accession BC053559

Human GRB14 Gene cDNA Clone (full-length ORF Clone), expression ready, N-His-tagged - HG14084-NH from Sino Biological Species Human Accession BC053559

Human GRB14 natural ORF mammalian expression plasmid, N-Flag tag - HG14084-NF from Sino Biological Species Human Accession BC053559

Human GRB14 Gene cDNA Clone (full-length ORF Clone), expression ready, N-Myc-tagged - HG14084-NM from Sino Biological Species Human Accession BC053559

Human GRB14 Gene cDNA Clone (full-length ORF Clone), expression ready, C-FLAG-tagged - HG14084-CF from Sino Biological Species Human Accession BC053559

Human GRB14 Gene cDNA Clone (full-length ORF Clone), expression ready, C-His-tagged - HG14084-CH from Sino Biological Species Human Accession BC053559

Human GRB14 Gene cDNA Clone (full-length ORF Clone), expression ready, C-Myc-tagged - HG14084-CM from Sino Biological Species Human Accession BC053559

Human GRB14 Gene cDNA Clone (full-length ORF Clone), expression ready, N-HA-tagged - HG14084-NY from Sino Biological Species Human Accession BC053559

Human GRB14 natural ORF mammalian expression plasmid, N-GFPSpark tag - HG14084-ANG from Sino Biological Species Human Accession BC053559

Human GRB14 ORF Clone (BC053559) - CDCS411814 from Creative biogene Species Human Accession Q14449

Human GRB14 ORF clone (BC053559) - CDCB159403 from Creative biogene Species Human

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