GRB14

Gene Symbol	GRB14
Entrez Gene	2888
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	growth factor receptor-bound protein 14
Other Description	GRB14 adapter protein
Swissprots	Q14449 B7Z7F9 Q7Z6I1
Accessions	AAY14768 AAY24176 EAX11342 EAX11343 Q14449 AK301961 BAH13595 AK302129 BAH13632 AK307744 AK309590 AK313153 BAG35971 BC053559 AAH53559 CN266581 DB560753 DC359097 EU832411 ACE86896 L76687 AAC15861 XM_006712457 XP_006712520 XM_011511022 XP_011509324 XR_427085 NM_001303422 NP_001290351 NM_004490 NP_004481
Function	Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}.
Subcellular Location	Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Upon insulin stimulation, translocates to the plasma membrane.
Tissue Specificity	Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GRB 14 protein (His-DHFR tag) - ab127666 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

GRB14 Antibody Blocking Peptide - LS-E23196 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human GRB 14 Protein - H00002888-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

GRB14 Blocking Peptide - abx062693 from Abbexa Category Peptide Species Human

GRB14 - H00002888-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

GRB14 - H00002888-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GRB14 fusion protein - Ag6455 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

GRB14 fusion protein - Ag7554 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human GRB14, His-tagged - GRB14-13519H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human GRB14 Protein, MYC/DDK-tagged - GRB14-538H from Creative Biomart Category Protein Source HEK293 Species Human

GRB14 Blocking Peptide - CBP1499 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

GRB14 (D123) Peptide - BS3130P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Growth factor receptor-bound protein 14(GRB14) - CSB-YP009888HU CSB-EP009888HU CSB-BP009888HU CSB-MP009888HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

GRB14 Protein - abx164150 from Abbexa Category Protein Species Human, Mouse, Rat

GRB14 - TP316110 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

GRB 14 Recombinant Protein Antigen - NBP2-38230PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

GRB14-Antibody-N-term-Blocking-Peptide - BP8969a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GRB14 Peptide, Human - M34GP06635H from Creative Peptides Category Peptide Source Synthetic. Species Human

Growth Factor Receptor Bound Protein 14 (Grb14), Recombinant Protein - MBS2086920 from MyBioSource Category Protein Prices $150.00, $295.00, $465.00 Sizes 10 µg, 50 µg, 100 µg Source E Coli Species Human

Growth factor receptor-bound protein 14 (GRB14), Recombinant Protein - MBS1438511 from MyBioSource Category Protein Prices $1,330.00, $1,330.00, $1,550.00, $1,550.00, $2,205.00, $2,205.00, $2,670.00, $2,670.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

GRB14 peptide - orb217362 from Biorbyt Category Peptide Species Human

Recombinant Human GRB14 Protein, His-tagged - GRB14-1432H from Creative Biomart Category Protein Source E. coli Species Human

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