| Gene Symbol |
LOXL2
|
| Entrez Gene |
4017
|
| Alt Symbol |
LOR2, WS9-14
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysyl oxidase-like 2
|
| Other Description |
lysyl oxidase homolog 2|lysyl oxidase related 2|lysyl oxidase-like 2 delta e13|lysyl oxidase-like 2 protein|lysyl oxidase-like protein 2|lysyl oxidase-related protein 2|lysyl oxidase-related protein WS9-14
|
| Swissprots |
B2R5Q0 Q9Y4K0 Q9Y5Y8 Q9BW70 Q53HV3
|
| Accessions |
EAW63625 EAW63626 EAW63627 Q9Y4K0 AF117949 AAD34343 AK098436 AK124508 AK222477 BAD96197 AK293292 BAG56815 AK312266 BAG35197 BC000594 AAH00594 BC020481 DQ892685 ABM83611 DQ895929 ABM86855 KF928961 AHJ59530 KF975332 AHL69790 U89942 AAB49697 NM_002318 NP_002309
|
| Function |
Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E- cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Nucleus. Chromosome. Note=Associated with chromatin. It is unclear how LOXL2 is nuclear: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, different reports confirmed the intracellular location and its key role in transcription regulation.
|
| Tissue Specificity |
Expressed in many tissues. Highest expression in reproductive tissues, placenta, uterus and prostate. Up- regulated in a number of cancers cells and tissues.
|
![Western Blot: LOXL2 Overexpression Lysate (Adult Normal) [NBL1-12641] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LOXL2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1389_LOXL2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12641-img0002.jpg)