LOXL2
| Gene Symbol | LOXL2 |
|---|---|
| Entrez Gene | 4017 |
| Alt Symbol | LOR2, WS9-14 |
| Species | Human |
| Gene Type | protein-coding |
| Description | lysyl oxidase-like 2 |
| Other Description | lysyl oxidase homolog 2|lysyl oxidase related 2|lysyl oxidase-like 2 delta e13|lysyl oxidase-like 2 protein|lysyl oxidase-like protein 2|lysyl oxidase-related protein 2|lysyl oxidase-related protein WS9-14 |
| Swissprots | B2R5Q0 Q9Y4K0 Q9Y5Y8 Q9BW70 Q53HV3 |
| Accessions | EAW63625 EAW63626 EAW63627 Q9Y4K0 AF117949 AAD34343 AK098436 AK124508 AK222477 BAD96197 AK293292 BAG56815 AK312266 BAG35197 BC000594 AAH00594 BC020481 DQ892685 ABM83611 DQ895929 ABM86855 KF928961 AHJ59530 KF975332 AHL69790 U89942 AAB49697 NM_002318 NP_002309 |
| Function | Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E- cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role |
| Subcellular Location | Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Nucleus. Chromosome. Note=Associated with chromatin. It is unclear how LOXL2 is nuclear: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, different reports confirmed the intracellular location and its key role in transcription regulation. |
| Tissue Specificity | Expressed in many tissues. Highest expression in reproductive tissues, placenta, uterus and prostate. Up- regulated in a number of cancers cells and tissues. |
LOXL2 CRISPR/Cas9 KO Plasmid (h) - sc-401021 from Santa Cruz Biotechnology
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LOXL2 HDR Plasmid (h) - sc-401021-HDR from Santa Cruz Biotechnology
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LOXL2 Double Nickase Plasmid (h) - sc-401021-NIC from Santa Cruz Biotechnology
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LOXL2 Double Nickase Plasmid (h2) - sc-401021-NIC-2 from Santa Cruz Biotechnology
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LOXL2 CRISPR Activation Plasmid (h) - sc-401021-ACT from Santa Cruz Biotechnology
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LOXL2 CRISPR Activation Plasmid (h2) - sc-401021-ACT-2 from Santa Cruz Biotechnology
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LOXL2 Lentiviral Activation Particles (h) - sc-401021-LAC from Santa Cruz Biotechnology
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LOXL2 Lentiviral Activation Particles (h2) - sc-401021-LAC-2 from Santa Cruz Biotechnology
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LOXL2 siRNA (h) - sc-45222 from Santa Cruz Biotechnology
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LOXL2 shRNA Plasmid (h) - sc-45222-SH from Santa Cruz Biotechnology
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LOXL2 shRNA (h) Lentiviral Particles - sc-45222-V from Santa Cruz Biotechnology
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Lysyl Oxidase Homolog 2/LOXL2 RNAi - H00004017-R01 from Novus Biologicals
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MISSION® esiRNA - EHU109481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2074 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2074 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08306 from Sigma-Aldrich
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LOXL2 siRNA (Human) - CRH2721 from Cohesion Biosciences
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shRNA set against Human LOXL2 (NM_002318.2) - SHH333347 from Creative biogene
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shRNA set against Human LOXL2(NM_002318.2) - SHH159491 from Creative biogene
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LOXL2 shRNA Plasmid (Human) - CHH2721 from Cohesion Biosciences
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LOXL2 miRNA 3'UTR clone - MiUTR1H-05877 from Creative biogene
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