LOXL2

Gene Symbol	LOXL2
Entrez Gene	4017
Alt Symbol	LOR2, WS9-14
Species	Human
Gene Type	protein-coding
Description	lysyl oxidase-like 2
Other Description	lysyl oxidase homolog 2|lysyl oxidase related 2|lysyl oxidase-like 2 delta e13|lysyl oxidase-like 2 protein|lysyl oxidase-like protein 2|lysyl oxidase-related protein 2|lysyl oxidase-related protein WS9-14
Swissprots	B2R5Q0 Q9Y4K0 Q9Y5Y8 Q9BW70 Q53HV3
Accessions	EAW63625 EAW63626 EAW63627 Q9Y4K0 AF117949 AAD34343 AK098436 AK124508 AK222477 BAD96197 AK293292 BAG56815 AK312266 BAG35197 BC000594 AAH00594 BC020481 DQ892685 ABM83611 DQ895929 ABM86855 KF928961 AHJ59530 KF975332 AHL69790 U89942 AAB49697 NM_002318 NP_002309
Function	Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E- cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role
Subcellular Location	Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Nucleus. Chromosome. Note=Associated with chromatin. It is unclear how LOXL2 is nuclear: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, different reports confirmed the intracellular location and its key role in transcription regulation.
Tissue Specificity	Expressed in many tissues. Highest expression in reproductive tissues, placenta, uterus and prostate. Up- regulated in a number of cancers cells and tissues.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LOXL2 protein fragment - ab152505 from Abcam Category Protein Source Wheat germ Species Human

Human LOXL2 protein fragment - ab172185 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human LOXL2 protein fragment - ab95446 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

LOXL2 Antibody Blocking Peptide - LS-E3933 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LOXL2 Antibody Blocking Peptide - LS-E19709 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LOXL2 Antibody Blocking Peptide - LS-E29615 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

LOXL2 Antibody Blocking Peptide - LS-E29616 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

LOXL2 Antibody Blocking Peptide - LS-E29617 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Lysyl Oxidase Homolog 2/LOXL2 Protein - H00004017-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

LOXL2-Antibody-C-term-Blocking-Peptide - BP16131b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Lysyl Oxidase Homolog 2, CF - 2639-AO-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Met1-Gln774, with a C-terminal 10-His tag

Human LOR 2 protein - orb84523 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Human Species Human

Human LOXL2 (His Tag) protein - orb232265 from Biorbyt Category Protein Prices $400.00, $816.00 Sizes 10 μg, 50 μg Species Human

Loxl2 Blocking Peptide - 33R-6805 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human LOXL2 Protein - abx067877 from Abbexa Category Protein Source E.coli Species Human

Human LOXL2 Protein - abx067881 from Abbexa Category Protein Source E.coli Species Human

LOXL2 - H00004017-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

LOXL2 - H00004017-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Lysyl Oxidase Like Protein 2 (LOXL2), Human - 20-9094 from ARP American Research Products Category Protein Prices $569.00 Sizes 50 µg Source E.coli Species Human

Lysyl Oxidase Like Protein 2 (LOXL2), Human - 20-9095 from ARP American Research Products Category Protein Prices $569.00 Sizes 50 µg Source E.coli Species Human

LOXL2 fusion protein - Ag24397 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PET30a Species Human

LOXL2 fusion protein - ag7083 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

LOXL2 fusion protein - ag8349 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Lysyl Oxidase-like 2 (LOXL2) Human Recombinant Protein (293) - GWB-PS620F from Genway Biotech Category Protein Prices $600.00 Sizes 10 µg Species Human

Lysyl Oxidase-like 2 (LOXL2) Human Recombinant Protein - GWB-A8612E from Genway Biotech Category Protein Prices $600.00 Sizes 10 µg Species Human

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