LOXL2

Gene Symbol	LOXL2
Entrez Gene	4017
Alt Symbol	LOR2, WS9-14
Species	Human
Gene Type	protein-coding
Description	lysyl oxidase-like 2
Other Description	lysyl oxidase homolog 2\|lysyl oxidase related 2\|lysyl oxidase-like 2 delta e13\|lysyl oxidase-like 2 protein\|lysyl oxidase-like protein 2\|lysyl oxidase-related protein 2\|lysyl oxidase-related protein WS9-14
Swissprots	B2R5Q0 Q9Y4K0 Q9Y5Y8 Q9BW70 Q53HV3
Accessions	EAW63625 EAW63626 EAW63627 Q9Y4K0 AF117949 AAD34343 AK098436 AK124508 AK222477 BAD96197 AK293292 BAG56815 AK312266 BAG35197 BC000594 AAH00594 BC020481 DQ892685 ABM83611 DQ895929 ABM86855 KF928961 AHJ59530 KF975332 AHL69790 U89942 AAB49697 NM_002318 NP_002309
Function	Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E- cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role
Subcellular Location	Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Nucleus. Chromosome. Note=Associated with chromatin. It is unclear how LOXL2 is nuclear: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, different reports confirmed the intracellular location and its key role in transcription regulation.
Tissue Specificity	Expressed in many tissues. Highest expression in reproductive tissues, placenta, uterus and prostate. Up- regulated in a number of cancers cells and tissues.

LOXL2 (F-13) - sc-48723 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

LOXL2 (F-13): sc-48723. Immunoperoxidase staining of formalin fixed, paraffin-embedded human thyroid gland tissue showing cytoplasmic and nuclear staining of glandular cells.

LOXL2 (H-65) - sc-66950 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

LOXL2 (H-65): sc-66950. Immunoperoxidase staining of formalin fixed, paraffin-embedded human rectum tissue showing cytoplasmic staining of glandular cells.

LOXL2 (N-15) - sc-48724 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-LOXL2 antibody - ab96233 from Abcam

Prices	$387.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-LOXL2 antibody (ab96233) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : A431 cell lysateLane 3 : H1299 cell lysateLysates/proteins at 30 µg per lane.

Anti-LOXL2 antibody - ab140833 from Abcam

Prices	$387.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

ab140833 staining LOXL2 in mouse tail tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde, permeabilized with 0.2% Triton X-100 in PBS and blocked with 5% milk for 30 minutes at room temperature; antigen retrieval was via the microwave method for 5 minutes. Samples were incubated with primary antibody (1/100 in PBS) for 16 hours at 4°C. An undiluted Biotin-conjugated goat anti-rabbit IgG polyclonal was used as the secondary antibody.See Abreview

Anti-LOXL2 antibody - ab133383 from Abcam

Prices	$376.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of formalin-fixed, paraffin embedded Human prostate tissue labelling LOXL2 with ab133383 at 15µg/ml. Followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-LOXL2 antibody - ab197779 from Abcam

Prices	$376.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human prostate tissue labeling LOXL2 using ab197779 at 5 µg/ml.

Anti-LOXL2 antibody - ab55470 from Abcam

Prices	$378.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-LOXL2 antibody - ab113201 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-LOXL2 antibody (ab113201) at 1 µg/mlLane 1 : LNCaP human prostate carcinoma cell line lysate Whole Cell LysateLane 2 : DU 145 (Human prostate carcinoma cell line) Whole Cell LysateLane 3 : A431 (Human epithelial carcinoma cell line) Whole Cell LysateLane 4 : A549 (Human lung adenocarcinoma epithelial cell line) Whole Cell LysateLane 5 : MDA-MB-231 (Human breast adenocarcinoma cell line) Whole Cell Lysate Lane 6 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-LOXL2 antibody - ab124117 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-LOXL2 antibody (ab124117) at 1/100 dilution + A549 cell line lysates at 35 µg

Anti-LOXL2 antibody - ab113960 from Abcam

Prices	$376.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-LOXL2 antibody (ab113960) at 1 µg/ml + Mouse heart lysate at 10 µg

Anti-LOXL2 antibody [EPR12733] - C-terminal - ab179810 from Abcam

Prices	$385.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR12733

All lanes : Anti-LOXL2 antibody [EPR12733] - C-terminal (ab179810) at 1/1000 dilutionLane 1 : Human fetal brain lysateLane 2 : Human breast cancer lysateLane 3 : MDA-MB-435 lysateLane 4 : U87-MG lysateLane 5 : MCF7 lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-LOXL2 Antibody (aa607-656) - LS-C135321 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

LOXL2 antibody LS-C135321 Western blot of Mouse Heart lysate. Antibody concentration 1 ug/ml.

Anti-LOXL2 Antibody (aa589-617, PE) - LS-C215648 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-LOXL2 Antibody (aa434-546) - LS-C295243 from LifeSpan Bioscience

Prices	$425.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-LOXL2 Antibody (aa53-160, Biotin) - LS-C298477 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-LOXL2 Antibody (aa323-427, Biotin) - LS-C298478 from LifeSpan Bioscience

Prices	$425.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-LOXL2 Antibody (clone 5D2) - LS-C197624 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	5D2

Detection limit for recombinant GST tagged LOXL2 is approximately 0.3 ng/ml as a capture antibody.

Anti-LOXL2 Antibody (aa434-546, Biotin) - LS-C298481 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-LOXL2 Antibody (aa53-160, Biotin) - LS-C299839 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-LOXL2 Antibody (aa553-761, Biotin) - LS-C299994 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-LOXL2 Antibody (aa589-617) - LS-C165845 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

LOXL2 Antibody western blot of A549 cell line lysates (35 ug/lane). The LOXL2 antibody detected the LOXL2 protein (arrow).

Anti-LOXL2 Antibody (aa323-427, FITC) - LS-C301841 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-LOXL2 Antibody (aa53-160) - LS-C295242 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-LOXL2 Antibody (aa53-160, FITC) - LS-C301842 from LifeSpan Bioscience

Prices	$465.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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