LOXL2

Gene Symbol	LOXL2
Entrez Gene	4017
Alt Symbol	LOR2, WS9-14
Species	Human
Gene Type	protein-coding
Description	lysyl oxidase-like 2
Other Description	lysyl oxidase homolog 2|lysyl oxidase related 2|lysyl oxidase-like 2 delta e13|lysyl oxidase-like 2 protein|lysyl oxidase-like protein 2|lysyl oxidase-related protein 2|lysyl oxidase-related protein WS9-14
Swissprots	B2R5Q0 Q9Y4K0 Q9Y5Y8 Q9BW70 Q53HV3
Accessions	EAW63625 EAW63626 EAW63627 Q9Y4K0 AF117949 AAD34343 AK098436 AK124508 AK222477 BAD96197 AK293292 BAG56815 AK312266 BAG35197 BC000594 AAH00594 BC020481 DQ892685 ABM83611 DQ895929 ABM86855 KF928961 AHJ59530 KF975332 AHL69790 U89942 AAB49697 NM_002318 NP_002309
Function	Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E- cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role
Subcellular Location	Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Nucleus. Chromosome. Note=Associated with chromatin. It is unclear how LOXL2 is nuclear: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, different reports confirmed the intracellular location and its key role in transcription regulation.
Tissue Specificity	Expressed in many tissues. Highest expression in reproductive tissues, placenta, uterus and prostate. Up- regulated in a number of cancers cells and tissues.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LOXL2 cDNA clone(NM_002318.2) - CDFH010581 from Creative Biomart Species Human Accession NM_002318.2

Human LOXL2 ORF Clone(NM_002318.2) - CDCR282952 from Creative Biomart Species Human Accession NM_002318.2

Human LOXL2 ORF Clone(NM_002318.2) - CDCR282953 from Creative Biomart Species Human Accession NM_002318.2

Human LOXL2 ORF Clone(NM_002318.2) - CDCL169050 from Creative Biomart Species Human Accession NM_002318.2

Human LOXL2 ORF clone(NM_002318.2) - CDCL185181 from Creative Biomart Species Human Accession NM_002318.2

Human LOXL2/Lysyl oxidase-like 2 Gene ORF cDNA clone in cloning vector - HG11664-M from Sino Biological Species Human

Human LOXL2/Lysyl oxidase-like 2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11664-ACG from Sino Biological Species Human

Human LOXL2/Lysyl oxidase-like 2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11664-NF from Sino Biological Species Human

Human LOXL2/Lysyl oxidase-like 2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11664-CF from Sino Biological Species Human

Human LOXL2/Lysyl oxidase-like 2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11664-NM from Sino Biological Species Human

Human LOXL2/Lysyl oxidase-like 2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11664-NY from Sino Biological Species Human

Human LOXL2/Lysyl oxidase-like 2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11664-CM from Sino Biological Species Human

Human LOXL2/Lysyl oxidase-like 2 Gene ORF cDNA clone expression plasmid, N-His tag - HG11664-NH from Sino Biological Species Human

Human LOXL2/Lysyl oxidase-like 2 Gene ORF cDNA clone expression plasmid - HG11664-UT from Sino Biological Species Human

Human LOXL2/Lysyl oxidase-like 2 Gene ORF cDNA clone expression plasmid, C-His tag - HG11664-CH from Sino Biological Species Human

Human LOXL2/Lysyl oxidase-like 2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11664-CY from Sino Biological Species Human

Human LOXL2 ORF clone(NM_002318.2) - CDCL185181 from Creative biogene Species Human

Human LOR 2 Gene - orb92773 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human LOXL2 cDNA Clone(NM_002318.2) - CDFH010581 from Creative biogene Species Human

Human LOXL2/Lysyl oxidase-like 2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11664-ACR from Sino Biological Species Human

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