MIXL1

Gene Symbol MIXL1
Entrez Gene 83881
Alt Symbol MILD1, MIX, MIXL
Species Human
Gene Type protein-coding
Description Mix paired-like homeobox
Other Description MIX1 homeobox-like protein 1|Mix-like homeobox protein 1|homeobox protein MIXL1|homeodomain protein MIX|mix.1 homeobox-like protein
Swissprots B7ZLF9 Q9H2W2
Accessions AAK01479 EAW69778 EAW69779 Q9H2W2 AF211891 AAG35776 BC111974 AAI11975 BC113441 AAI13442 BC143784 AAI43785 CX165667 XM_011544287 XP_011542589 NM_001282402 NP_001269331 NM_031944 NP_114150
Function Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000269|PubMed:12070013, ECO:0000269|PubMed:17303500}.
Tissue Specificity Restricted to progenitors and secondary lymph tissues. In normal hematopoiesis, it is restricted to immature B- and T-lymphoid cells. Present in differentiating embryonic stem cells (at protein level). {ECO:0000269|PubMed:12070013, ECO:0000269|PubMed:16433620, ECO:0000269|PubMed:17303500}.

Panoply™ Human MIXL1 Knockdown Stable Cell Line - CSC-DC009539 from Creative biogene

Category Cell Line
Species Human
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