| Gene Symbol |
MIXL1
|
| Entrez Gene |
83881
|
| Alt Symbol |
MILD1, MIX, MIXL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Mix paired-like homeobox
|
| Other Description |
MIX1 homeobox-like protein 1|Mix-like homeobox protein 1|homeobox protein MIXL1|homeodomain protein MIX|mix.1 homeobox-like protein
|
| Swissprots |
B7ZLF9 Q9H2W2
|
| Accessions |
AAK01479 EAW69778 EAW69779 Q9H2W2 AF211891 AAG35776 BC111974 AAI11975 BC113441 AAI13442 BC143784 AAI43785 CX165667 XM_011544287 XP_011542589 NM_001282402 NP_001269331 NM_031944 NP_114150
|
| Function |
Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000269|PubMed:12070013, ECO:0000269|PubMed:17303500}.
|
| Tissue Specificity |
Restricted to progenitors and secondary lymph tissues. In normal hematopoiesis, it is restricted to immature B- and T-lymphoid cells. Present in differentiating embryonic stem cells (at protein level). {ECO:0000269|PubMed:12070013, ECO:0000269|PubMed:16433620, ECO:0000269|PubMed:17303500}.
|