| Gene Symbol |
FIGLA
|
| Entrez Gene |
344018
|
| Alt Symbol |
BHLHC8, FIGALPHA, POF6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
folliculogenesis specific basic helix-loop-helix
|
| Other Description |
class C basic helix-loop-helix protein 8|factor in the germline alpha|folliculogenesis-specific basic helix-loop-helix protein|transcription factor FIGa
|
| Swissprots |
Q6QHK4
|
| Accessions |
EAW99795 EAW99796 EAW99797 Q6QHK4 AY541030 AAS48452 BC039536 BC146287 AAI46288 BC148798 AAI48799 NM_001004311 NP_001004311
|
| Function |
Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E- box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters. {ECO:0000269|PubMed:15044608}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Germ cells. Expressed in the fetal ovary, but not by a range of other tissues. Expression increases across mid- gestation, rising some 40-fold by the time of primordial follicle formation. {ECO:0000269|PubMed:12468641, ECO:0000269|PubMed:15044608}.
|