FIGLA

Gene Symbol FIGLA
Entrez Gene 344018
Alt Symbol BHLHC8, FIGALPHA, POF6
Species Human
Gene Type protein-coding
Description folliculogenesis specific basic helix-loop-helix
Other Description class C basic helix-loop-helix protein 8|factor in the germline alpha|folliculogenesis-specific basic helix-loop-helix protein|transcription factor FIGa
Swissprots Q6QHK4
Accessions EAW99795 EAW99796 EAW99797 Q6QHK4 AY541030 AAS48452 BC039536 BC146287 AAI46288 BC148798 AAI48799 NM_001004311 NP_001004311
Function Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E- box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters. {ECO:0000269|PubMed:15044608}.
Subcellular Location Nucleus {ECO:0000305}.
Tissue Specificity Germ cells. Expressed in the fetal ovary, but not by a range of other tissues. Expression increases across mid- gestation, rising some 40-fold by the time of primordial follicle formation. {ECO:0000269|PubMed:12468641, ECO:0000269|PubMed:15044608}.

Human FIGLA ORF clone (NM_001004311.3) - CDCL108385 from Creative biogene

Species Human
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