FIGLA

Gene Symbol FIGLA
Entrez Gene 344018
Alt Symbol BHLHC8, FIGALPHA, POF6
Species Human
Gene Type protein-coding
Description folliculogenesis specific basic helix-loop-helix
Other Description class C basic helix-loop-helix protein 8|factor in the germline alpha|folliculogenesis-specific basic helix-loop-helix protein|transcription factor FIGa
Swissprots Q6QHK4
Accessions EAW99795 EAW99796 EAW99797 Q6QHK4 AY541030 AAS48452 BC039536 BC146287 AAI46288 BC148798 AAI48799 NM_001004311 NP_001004311
Function Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E- box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters. {ECO:0000269|PubMed:15044608}.
Subcellular Location Nucleus {ECO:0000305}.
Tissue Specificity Germ cells. Expressed in the fetal ovary, but not by a range of other tissues. Expression increases across mid- gestation, rising some 40-fold by the time of primordial follicle formation. {ECO:0000269|PubMed:12468641, ECO:0000269|PubMed:15044608}.

FIGLA CRISPR/Cas9 KO Plasmid (h) - sc-415593 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FIGLA HDR Plasmid (h) - sc-415593-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FIGLA Double Nickase Plasmid (h) - sc-415593-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FIGLA Double Nickase Plasmid (h2) - sc-415593-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FIGLA CRISPR Activation Plasmid (h) - sc-415593-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FIGLA CRISPR Activation Plasmid (h2) - sc-415593-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FIGLA Lentiviral Activation Particles (h) - sc-415593-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FIGLA Lentiviral Activation Particles (h2) - sc-415593-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FIGLA siRNA (h) - sc-94652 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FIGLA shRNA Plasmid (h) - sc-94652-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FIGLA shRNA (h) Lentiviral Particles - sc-94652-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FIGLA RNAi - H00344018-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN8694 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8694 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FIGLA siRNA (Human) - CRJ7442 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FIGLA - MBS8205251 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FIGLA (NM_001004311.3) - SHH295013 from Creative biogene

Category siRNA
Species Reactivities Human

FIGLA shRNA Plasmid (Human) - CHJ7442 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FIGLA miRNA 3'UTR clone - MiUTR4H-TG03554 from Creative biogene

Species Reactivities Human
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