DNMT3A

Gene Symbol	DNMT3A
Entrez Gene	1788
Alt Symbol	DNMT3A2, M.HsaIIIA, TBRS
Species	Human
Gene Type	protein-coding
Description	DNA (cytosine-5-)-methyltransferase 3 alpha
Other Description	DNA (cytosine-5)-methyltransferase 3A|DNA MTase HsaIIIA|DNA cytosine methyltransferase 3A2
Swissprots	Q86TE8 Q8WXU9 Q8IZV0 Q86XF5 E9PEB8 Q9Y6K1
Accessions	AAY14761 EAX00727 EAX00728 Q9Y6K1 AB208833 BAD92070 AF067972 AAD33084 AF331856 AAL57039 AF480163 AAN40037 AI376254 AK025230 BC018214 AAH18214 BC023612 AAH23612 BC032392 AAH32392 BC043617 AAH43617 BC051864 AAH51864 BM470515 CB852889 EU446951 ABZ92480 W76111 XM_005264175 XP_005264232 XM_005264177 XP_005264234 XM_006711957 XP_006712020 XM_006711958 XP_006712021 XM_011532662 XP_011530964 XM_011532663 XP_011530965 XM_011532664 XP_011530966 XM_011532665 XP_011530967 XM_011532666 XP_011530968 XM_011532667 XP_011530969 XM_011532668 XP_011530970 NM_022552 NP_072046 NM_153759 NP_715640 NM_175629 NP_783328 NM_175630 NP_783329
Function	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. {ECO:0000269|PubMed:16357870}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12145218}. Cytoplasm {ECO:0000269|PubMed:12145218}. Note=Accumulates in the major satellite repeats at pericentric heterochromatin. {ECO:0000250}.
Tissue Specificity	Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung. {ECO:0000269|PubMed:10325416}.
Top Pathways	Cysteine and methionine metabolism, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DNMT3A ELISA Kit (Sandwich ELISA) - LS-F9225 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

DNMT3A Colorimetric Assay Kit - KA0683 from Novus Biologicals Category Assay Kit Prices $799.00 Sizes 1 kit

Human DNMT3A ELISA Kit - abx151333 from Abbexa Category ELISA Kit Sensitivity 0.061 ng/ml Range 0.156 ng/ml - 10 ng/ml

DNA Methyltransferase 3A (DNMT3A), Human, ELISA Kit - SEJ245Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.059ng/mL Range 0.156-10ng/mL

DNMT3A (Human) IP-WB Antibody Pair - H00001788-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

DNA (cytosine-5-) -methyltransferase 3 alpha, ELISA Kit - MBS9310055 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNMT3A, ELISA Kit - MBS2515871 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

DNMT3A, ELISA Kit - MBS2515699 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

ELISA Kit for DNA Methyltransferase 3A (DNMT3A) - SEJ245Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for DNA Methyltransferase 3A (DNMT3A) - SEJ245Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

DNMT3A Assay Kit - KA0683 from Acris Antibodies Category Assay Kit Prices $650.00 Sizes 1 kit

Human DNMT3A(DNA Methyltransferase 3A) ELISA Kit - E-EL-H5428 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mL Range 0.16~10 ng/mL

Human DNMT3A ELISA Kit (Sandwich ELISA) - LS-F21288 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.094 ng/ml Range 0.156-10 ng/ml

Rat DNMT3A ELISA Kit (Sandwich ELISA) - LS-F21638 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.094 ng/ml Range 0.156-10 ng/ml

DNA Methyltransferase 3A (DNMT3A), Human, ELISA Kit - DL-DNMT3A-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human DNMT3A(DNA Methyltransferase 3A) ELISA Kit - E-EL-H5428 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

DNA Methyltransferase 3A, DNMT3A, Human, ELISA Kit - E-EL-H5428 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Human DNMT3A ELISA Kit - abx571713 from Abbexa Category ELISA Kit Sensitivity 0.059 ng/ml Range 0.156 ng/ml - 10 ng/ml

Custom Human DNMT3A ELISA - ELH-DNMT3A-1 from RayBiotech Category ELISA Kit Prices $627.00, $1,128.60, $2,508.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Custom Human DNMT3A ELISA Kit - orb384551 from Biorbyt Category ELISA Kit Prices $1,411.00, $2,448.00, $5,321.00 Sizes 96 assays, 192 assays, 480 assays

Human DNMT3A ELISA Kit - E012145 from Biobool Category ELISA Kit Sensitivity Typically less than 0.061ng/mL.

DNMT3A ELISA Kit (Human) (OKDD00235) - OKDD00235 from Aviva Systems Biology Category ELISA Kit Prices $580.00 Sizes 96 wells Sensitivity < 0.059 ng/mL Range 0.156-10 ng/mL

anti-Dnmt3a antibody - ARG56553 from Arigo Biolaboratories Category ELISA Kit

Human DNA (cytosine-5)-methyltransferase 3A (DNMT3A) ELISA Kit - AE62968HU from ARP American Research Products Category ELISA Kit Prices $612.00 Sizes 96 t Sensitivity 0.061 ng/mL Range 0.156-10 ng/mL

DNA Methyltransferase 3A (DNMT3A), ELISA Kit - MBS454211 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.059ng/mL Range 0.156-10ng/mL

Search more