DNMT3A

Gene Symbol	DNMT3A
Entrez Gene	1788
Alt Symbol	DNMT3A2, M.HsaIIIA, TBRS
Species	Human
Gene Type	protein-coding
Description	DNA (cytosine-5-)-methyltransferase 3 alpha
Other Description	DNA (cytosine-5)-methyltransferase 3A|DNA MTase HsaIIIA|DNA cytosine methyltransferase 3A2
Swissprots	Q86TE8 Q8WXU9 Q8IZV0 Q86XF5 E9PEB8 Q9Y6K1
Accessions	AAY14761 EAX00727 EAX00728 Q9Y6K1 AB208833 BAD92070 AF067972 AAD33084 AF331856 AAL57039 AF480163 AAN40037 AI376254 AK025230 BC018214 AAH18214 BC023612 AAH23612 BC032392 AAH32392 BC043617 AAH43617 BC051864 AAH51864 BM470515 CB852889 EU446951 ABZ92480 W76111 XM_005264175 XP_005264232 XM_005264177 XP_005264234 XM_006711957 XP_006712020 XM_006711958 XP_006712021 XM_011532662 XP_011530964 XM_011532663 XP_011530965 XM_011532664 XP_011530966 XM_011532665 XP_011530967 XM_011532666 XP_011530968 XM_011532667 XP_011530969 XM_011532668 XP_011530970 NM_022552 NP_072046 NM_153759 NP_715640 NM_175629 NP_783328 NM_175630 NP_783329
Function	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. {ECO:0000269|PubMed:16357870}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12145218}. Cytoplasm {ECO:0000269|PubMed:12145218}. Note=Accumulates in the major satellite repeats at pericentric heterochromatin. {ECO:0000250}.
Tissue Specificity	Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung. {ECO:0000269|PubMed:10325416}.
Top Pathways	Cysteine and methionine metabolism, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DNMT3A - MBS1270923 from MyBioSource Species Human Accession BC043617

Human DNMT3A cDNA clone(NM_175630.1) - CDFG010574 from Creative Biomart Species Human Accession NM_175630.1

Human DNMT3A ORF Clone(NM_022552.4) - CDCL161371 from Creative Biomart Species Human Accession NM_022552.4

Human DNMT3A ORF Clone(NM_153759.3) - CDCR321016 from Creative Biomart Species Human Accession NM_153759.3

Human DNMT3A ORF Clone(NM_153759.3) - CDCR321017 from Creative Biomart Species Human Accession NM_153759.3

Human DNMT3A ORF Clone(NM_175630.1) - CDCR322693 from Creative Biomart Species Human Accession NM_175630.1

Human DNMT3A ORF Clone(NM_175630.1) - CDCR322694 from Creative Biomart Species Human Accession NM_175630.1

Human DNMT3A Gene ORF cDNA clone in cloning vector - HG11320-M from Sino Biological Species Human

Human DNMT3A Gene ORF cDNA clone expression plasmid, N-His tag - HG11320-NH from Sino Biological Species Human

Human DNMT3A Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11320-ACG from Sino Biological Species Human

Human DNMT3A Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11320-NF from Sino Biological Species Human

Human DNMT3A Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11320-NM from Sino Biological Species Human

Human DNMT3A Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11320-CF from Sino Biological Species Human

Human DNMT3A Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11320-CM from Sino Biological Species Human

Human DNMT3A Gene ORF cDNA clone expression plasmid, N-HA tag - HG11320-NY from Sino Biological Species Human

Human DNMT3A Gene ORF cDNA clone expression plasmid, C-His tag - HG11320-CH from Sino Biological Species Human

Human DNMT3A Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11320-ANG from Sino Biological Species Human

Human DNMT3A Gene ORF cDNA clone expression plasmid - HG11320-UT from Sino Biological Species Human

Human DNMT3A Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11320-ACR from Sino Biological Species Human

Human DNMT3A Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11320-ANR from Sino Biological Species Human

Human DNMT3A Gene ORF cDNA clone expression plasmid, C-HA tag - HG11320-CY from Sino Biological Species Human

Human DNMT3A ORF Clone(NM_153759.3) - CDCR321016 from Creative biogene Species Human

Human DNMT3A ORF clone (NM_175630.1) - CDCR056744 from Creative biogene Species Human

Human DNMT3A ORF Clone (BC043617) - CDCS415519 from Creative biogene Species Human Accession Q9Y6K1

Human DNMT3A ORF clone (NM_022552.3) - CDCB160419 from Creative biogene Species Human

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