| Gene Symbol |
DNMT3A
|
| Entrez Gene |
1788
|
| Alt Symbol |
DNMT3A2, M.HsaIIIA, TBRS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DNA (cytosine-5-)-methyltransferase 3 alpha
|
| Other Description |
DNA (cytosine-5)-methyltransferase 3A|DNA MTase HsaIIIA|DNA cytosine methyltransferase 3A2
|
| Swissprots |
Q86TE8 Q8WXU9 Q8IZV0 Q86XF5 E9PEB8 Q9Y6K1
|
| Accessions |
AAY14761 EAX00727 EAX00728 Q9Y6K1 AB208833 BAD92070 AF067972 AAD33084 AF331856 AAL57039 AF480163 AAN40037 AI376254 AK025230 BC018214 AAH18214 BC023612 AAH23612 BC032392 AAH32392 BC043617 AAH43617 BC051864 AAH51864 BM470515 CB852889 EU446951 ABZ92480 W76111 XM_005264175 XP_005264232 XM_005264177 XP_005264234 XM_006711957 XP_006712020 XM_006711958 XP_006712021 XM_011532662 XP_011530964 XM_011532663 XP_011530965 XM_011532664 XP_011530966 XM_011532665 XP_011530967 XM_011532666 XP_011530968 XM_011532667 XP_011530969 XM_011532668 XP_011530970 NM_022552 NP_072046 NM_153759 NP_715640 NM_175629 NP_783328 NM_175630 NP_783329
|
| Function |
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. {ECO:0000269|PubMed:16357870}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12145218}. Cytoplasm {ECO:0000269|PubMed:12145218}. Note=Accumulates in the major satellite repeats at pericentric heterochromatin. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung. {ECO:0000269|PubMed:10325416}.
|
| Top Pathways |
Cysteine and methionine metabolism, MicroRNAs in cancer
|
![Western Blot: Dnmt3a Cell Lysate [NBP2-25063] - analysis of 10 ul of Dnmt3atransfected and untransfected HEK293 celllysate probed with 1 ug/ml of Dnmt3a (clone 64B814.1) (Aand B) or Dnmt3a (Clone 64B1446) (C and D).](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/57_Dnmt3a-Cell-Lysate-Western-Blot-NBP2-25063-img0001.jpg)
![Western Blot: Dnmt3a Overexpression Lysate (Adult Normal) [NBL1-09970] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Dnmt3a.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11218_Dnmt3a%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-09970-img0002.jpg)
![Western Blot: Dnmt3a Overexpression Lysate (Adult Normal) [NBP2-05064] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Dnmt3a.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5794_Dnmt3a%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05064-img0001.jpg)
![Western Blot: Dnmt3a Overexpression Lysate (Adult Normal) [NBP2-10027] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Dnmt3a.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1539_Dnmt3a%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10027-img0001.jpg)