DNMT3A

Gene Symbol DNMT3A
Entrez Gene 1788
Alt Symbol DNMT3A2, M.HsaIIIA, TBRS
Species Human
Gene Type protein-coding
Description DNA (cytosine-5-)-methyltransferase 3 alpha
Other Description DNA (cytosine-5)-methyltransferase 3A|DNA MTase HsaIIIA|DNA cytosine methyltransferase 3A2
Swissprots Q86TE8 Q8WXU9 Q8IZV0 Q86XF5 E9PEB8 Q9Y6K1
Accessions AAY14761 EAX00727 EAX00728 Q9Y6K1 AB208833 BAD92070 AF067972 AAD33084 AF331856 AAL57039 AF480163 AAN40037 AI376254 AK025230 BC018214 AAH18214 BC023612 AAH23612 BC032392 AAH32392 BC043617 AAH43617 BC051864 AAH51864 BM470515 CB852889 EU446951 ABZ92480 W76111 XM_005264175 XP_005264232 XM_005264177 XP_005264234 XM_006711957 XP_006712020 XM_006711958 XP_006712021 XM_011532662 XP_011530964 XM_011532663 XP_011530965 XM_011532664 XP_011530966 XM_011532665 XP_011530967 XM_011532666 XP_011530968 XM_011532667 XP_011530969 XM_011532668 XP_011530970 NM_022552 NP_072046 NM_153759 NP_715640 NM_175629 NP_783328 NM_175630 NP_783329
Function Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. {ECO:0000269|PubMed:16357870}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12145218}. Cytoplasm {ECO:0000269|PubMed:12145218}. Note=Accumulates in the major satellite repeats at pericentric heterochromatin. {ECO:0000250}.
Tissue Specificity Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung. {ECO:0000269|PubMed:10325416}.
Top Pathways Cysteine and methionine metabolism, MicroRNAs in cancer

DNMT3A Antibody - 2160 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of cell extracts from 293, NIH/3T3 and H-4-II-E cells using DNMT3A Antibody.

DNMT3A (D23G1) Rabbit mAb - 3598 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D23G1
Western blot analysis of extracts from 293, NIH/3T3 and H-4-II-E cells using DNMT3A (D23G1) Rabbit mAb.

Dnmt3a (A-10) - sc-373905 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Dnmt3a (A-10): sc-373905. Western blot analysis of Dnmt3a expression in non-transfected: sc-117752 (A) and human Dnmt3a transfected: sc-115950 (B) 293T whole cell lysates.

Dnmt3a (C-12) - sc-365769 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Dnmt3a (C-12): sc-365769. Western blot analysis of Dnmt3a expression in non-transfected: sc-117752 (A) and mouse Dnmt3a transfected: sc-119814 (B) 293T whole cell lysates.

Dnmt3a (D-15) - sc-10232 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dnmt3a (D-15): sc-10232. Western blot analysis of Dnmt3a expression in non-transfected: sc-117752 (A) and human Dnmt3a transfected: sc-115950 (B) 293T whole cell lysates.

Dnmt3a (H-295) - sc-20703 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Dnmt3a (H-295): sc-20703. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing nuclear staining of trophoblastic cells and cytoplasmic staining of decidual cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Dnmt3a (P-16) - sc-10231 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dnmt3a (P-16): sc-10231. Western blot analysis of Dnmt3a expression in non-transfected: sc-117752 (A) and human Dnmt3a transfected: sc-115950 (B) 293T whole cell lysates.

Dnmt3a (64B1446) - sc-52921 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/500 µl
Host Mouse
Clonality Monoclonal
Dnmt3a (64B1446): sc-52921. Western blot analysis of Dnmt3a expression in non-transfected: sc-117752 (A) and human Dnmt3a transfected: sc-115950 (B) 293T whole cell lysates.

Dnmt3a (64B814) - sc-56656 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Dnmt3a (64B814): sc-56656. Western blot analysis of Dnmt3a expression in non-transfected: sc-117752 (A) and human Dnmt3a transfected: sc-115950 (B) 293T whole cell lysates.

Dnmt3a/b (C-15) - sc-10234 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dnmt3a/b (C-15): sc-10234. Western blot analysis of Dnmt3a expression in non-transfected: sc-117752 (A) and human Dnmt3a transfected: sc-115950 (B) 293T whole cell lysates.

Anti-Dnmt3a antibody - ab23565 from Abcam

Prices $398.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab23565 staining Dnmt3a in mouse lung tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with paraformaldehyde and blocked with 5% serum for 1 hour at 25°C; antigen retrieval was by heat mediation. Samples were incubated with primary antibody (1/300) for 24 hours at 4°C. A HRP-conjugated anti-rabbit IgG polyclonal (1/1000) was used as the secondary antibody.See Abreview

Anti-Dnmt3a antibody - ab14291 from Abcam

Prices $376.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
Anti-Dnmt3a antibody (ab14291) at 1/2000 dilution + E.coli. derived Dnmt3a fusion protein SecondaryHRP conjugated goat anti IgY at 1/1000 dilution

Anti-Dnmt3a antibody - ab135095 from Abcam

Host Rabbit
Clonality Polyclonal
Lane 1 : ab135095 (N2) at 1/1000 dilutionLane 2 : ab135095 (N) at 1/1000 dilutionLane 1 : Mouse thymus tissue extractLane 2 : Mouse thymus tissue extract

Anti-Dnmt3a antibody [64B1446] - ChIP Grade - ab13888 from Abcam

Prices $403.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 64B1446

Anti-Dnmt3a antibody [64B814] - ab13887 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 64B814

Anti-Dnmt3a antibody [64B814.1] - ab176147 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 64B814.1
All lanes : Anti-Dnmt3a antibody [64B814.1] (ab176147) at 3 µgLane 1 : Dnmt3 transfected 293 cell lysate(Human embryonic kidney cell line)Lane 2 : Non transfected 293 cell lysate

Anti-Dnmt3a antibody (Biotin) - ab200949 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Dnmt3a antibody [EPR2408] - ab134142 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2408
All lanes : Anti-Dnmt3a antibody [EPR2408] (ab134142) at 1/1000 dilutionLane 1 : SH SY5Y cell lysateLane 2 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-rabbit HRP at 1/2000 dilution

Anti-Dnmt3a antibody - ChIP Grade - ab2850 from Abcam

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Dnmt3a antibody - N-terminal - ab71424 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Dnmt3a antibody - N-terminal (ab71424) at 1/60 dilution + Jurkat cell line lysate at 35 µg

Anti-DNMT3A Antibody (aa472-487) - LS-C2988 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DNMT3A Antibody - LS-C6411 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DNMT3A Antibody (N-Terminus) - LS-C36168 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DNMT3A Antibody (Biotin) - LS-C64785 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-DNMT3A Antibody (clone 64B814.1) - LS-C521 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 64B814.1
Western blot analysis for Dnmt3a using antibody at 2 ug/ml against 10 ug of 293 cell lysate transfected with either mouse Dnmt3a (lane 1) or mouse Dnmt3b (lane 2).
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