HR

Gene Symbol HR
Entrez Gene 55806
Alt Symbol ALUNC, AU, HSA277165, HYPT4, MUHH, MUHH1
Species Human
Gene Type protein-coding
Description hair growth associated
Other Description hairless homolog|lysine-specific demethylase hairless|protein hairless
Swissprots Q6GS30 Q9NPE1 Q96H33 O43593
Accessions AIW82258 AIW82259 AIW82260 AIW82261 AIW82262 EAW63716 EAW63717 EAW63718 O43593 AF039196 AAC32258 AJ277165 CAB86602 AK098053 AK308839 AL833253 AW291630 BC008946 BC067128 AAH67128 BM982749 BX109092 DA114279 DA326731 XM_005273569 XP_005273626 XM_006716367 XP_006716430 NM_005144 NP_005135 NM_018411 NP_060881
Function Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. {ECO:0000269|PubMed:24334705}.
Subcellular Location Nucleus.
Tissue Specificity Strongest expression of isoforms 1 and 2 is seen in the small intestine, weaker expression in brain and colon, and trace expression is found in liver, pancreas, spleen, thymus, stomach, salivary gland, appendix and trachea. Isoform 1 is always the most abundant. Isoform 1 is exclusively expressed at low levels in kidney and testis. Isoform 2 is exclusively expressed at high levels in the skin. {ECO:0000269|PubMed:10051399, ECO:0000269|PubMed:9736769}.

HR (D-4) - sc-398176 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HR (D-4): sc-398176. Western blot analysis of HR expression in non-transfected: sc-117752 (A) and human HR transfected: sc-116984 (B) 293T whole cell lysates.

HR (N-17) - sc-87152 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

HR (P-16) - sc-87153 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

HR (366C2b) - sc-130015 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
HR (366C2b): sc-130015. Western blot analysis of human recombinant HR fusion protein.

HR (H-300) - sc-292827 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HR (H-300): sc-292827. Western blot analysis of HR expression in non-transfected: sc-117752 (A) and human HR transfected: sc-116984 (B) 293T whole cell lysates.

Anti-Hairless antibody - ab36682 from Abcam

Prices $242.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Hairless antibody - ab37540 from Abcam

Prices $242.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Hairless / HR Antibody (aa697-746) - LS-C30082 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate

Anti-Hairless / HR Antibody (aa170-219) - LS-C30083 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate

Anti-Hairless / HR Antibody - LS-C125694 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-Hairless / HR Antibody (Glu77) - LS-C193123 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Hairless / HR Antibody (N-Terminus, APC) - LS-C259858 from LifeSpan Bioscience

Prices $530.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Hairless / HR Antibody (N-Terminus, AP) - LS-C259859 from LifeSpan Bioscience

Prices $530.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Hairless / HR Antibody (N-Terminus, FITC) - LS-C259862 from LifeSpan Bioscience

Prices $530.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Hairless / HR Antibody (N-Terminus, Biotin) - LS-C259861 from LifeSpan Bioscience

Prices $530.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Hairless / HR Antibody (N-Terminus, Azide-free, HRP) - LS-C259863 from LifeSpan Bioscience

Prices $530.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Hairless / HR Antibody (N-Terminus, PE) - LS-C259864 from LifeSpan Bioscience

Prices $530.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Hairless / HR Antibody (aa41-90) - LS-C118684 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using HAIR Antibody. The picture on the right is treated with the synthesized peptide.

Anti-Hairless / HR Antibody (aa237-517) - LS-C311686 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Hairless / HR Antibody (N-Terminus) - LS-C329640 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Hairless / HR Antibody (clone 366C2b) - LS-C184610 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 366C2b
Western blot of immunized recombinant protein using HR antibody.

Anti-Hairless / HR Antibody (aa946-1189, clone 1D9) - LS-C340124 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D9
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HR (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HR.

Anti-Hairless / HR Antibody (clone 366C2b) - LS-C342642 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 366C2b
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-HR mAb. [366C2b-1]

Hairless Antibody [Unconjugated] - AF5708 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of HEK293 human embryonic kidney cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human Hairless Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5708) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for Hairless at approximately 96 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

Hairless Antibody - NBP1-55547 from Novus Biologicals

Prices $229.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: Hairless Antibody [NBP1-55547] - Analysis of A549 cells, using Hairless Antibody. The picture on the right is treated with the synthesized peptide.
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