Gene Symbol | HR |
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Entrez Gene | 55806 |
Alt Symbol | ALUNC, AU, HSA277165, HYPT4, MUHH, MUHH1 |
Species | Human |
Gene Type | protein-coding |
Description | hair growth associated |
Other Description | hairless homolog|lysine-specific demethylase hairless|protein hairless |
Swissprots | Q6GS30 Q9NPE1 Q96H33 O43593 |
Accessions | AIW82258 AIW82259 AIW82260 AIW82261 AIW82262 EAW63716 EAW63717 EAW63718 O43593 AF039196 AAC32258 AJ277165 CAB86602 AK098053 AK308839 AL833253 AW291630 BC008946 BC067128 AAH67128 BM982749 BX109092 DA114279 DA326731 XM_005273569 XP_005273626 XM_006716367 XP_006716430 NM_005144 NP_005135 NM_018411 NP_060881 |
Function | Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. {ECO:0000269|PubMed:24334705}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Strongest expression of isoforms 1 and 2 is seen in the small intestine, weaker expression in brain and colon, and trace expression is found in liver, pancreas, spleen, thymus, stomach, salivary gland, appendix and trachea. Isoform 1 is always the most abundant. Isoform 1 is exclusively expressed at low levels in kidney and testis. Isoform 2 is exclusively expressed at high levels in the skin. {ECO:0000269|PubMed:10051399, ECO:0000269|PubMed:9736769}. |
Human Hairless peptide - ab37538 from Abcam
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Human Hairless peptide - ab37539 from Abcam
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Human Hairless protein fragment - ab153410 from Abcam
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Hairless / HR Antibody Blocking Peptide - LS-E11589 from LifeSpan Bioscience
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Hairless / HR Antibody Blocking Peptide - LS-E11588 from LifeSpan Bioscience
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Recombinant Human Hairless Protein - H00055806-Q01 from Novus Biologicals
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Hairless / HR - H00055806-Q01-10 from Acris Antibodies
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Hairless / HR - H00055806-Q01-25 from Acris Antibodies
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HR fusion protein - Ag14181 from Proteintech Group
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HR fusion protein - Ag16992 from Proteintech Group
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Recombinant Human HR, GST-tagged - HR-13933H from Creative Biomart
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Hairless (E77) Peptide - BS9123P from Bioworld Technology
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Recombinant Human Protein hairless(HR) ,partial - CSB-YP010725HU CSB-EP010725HU CSB-BP010725HU CSB-MP010725HU from Cusabio
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Hairless / HR (transcript variant 1) - TP309010 from Acris Antibodies
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Hairless / HR (transcript variant 2) - TP321977 from Acris Antibodies
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HR12-Antibody-N-term-Blocking-Peptide - BP1011a from Abgent, a WuXi AppTec company
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HR Peptide, Human - M34GP07241H from Creative Peptides
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Viral PS/HR protein - orb54733 from Biorbyt
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Hairless Recombinant Protein Antigen - NBP2-58404PEP from Novus Biologicals
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Protein hairless (HR), partial, Recombinant Protein - MBS1091714 from MyBioSource
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