Gene Symbol | HR |
---|---|
Entrez Gene | 55806 |
Alt Symbol | ALUNC, AU, HSA277165, HYPT4, MUHH, MUHH1 |
Species | Human |
Gene Type | protein-coding |
Description | hair growth associated |
Other Description | hairless homolog|lysine-specific demethylase hairless|protein hairless |
Swissprots | Q6GS30 Q9NPE1 Q96H33 O43593 |
Accessions | AIW82258 AIW82259 AIW82260 AIW82261 AIW82262 EAW63716 EAW63717 EAW63718 O43593 AF039196 AAC32258 AJ277165 CAB86602 AK098053 AK308839 AL833253 AW291630 BC008946 BC067128 AAH67128 BM982749 BX109092 DA114279 DA326731 XM_005273569 XP_005273626 XM_006716367 XP_006716430 NM_005144 NP_005135 NM_018411 NP_060881 |
Function | Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. {ECO:0000269|PubMed:24334705}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Strongest expression of isoforms 1 and 2 is seen in the small intestine, weaker expression in brain and colon, and trace expression is found in liver, pancreas, spleen, thymus, stomach, salivary gland, appendix and trachea. Isoform 1 is always the most abundant. Isoform 1 is exclusively expressed at low levels in kidney and testis. Isoform 2 is exclusively expressed at high levels in the skin. {ECO:0000269|PubMed:10051399, ECO:0000269|PubMed:9736769}. |
HR CRISPR/Cas9 KO Plasmid (h) - sc-412612 from Santa Cruz Biotechnology
|
||||||||
HR HDR Plasmid (h) - sc-412612-HDR from Santa Cruz Biotechnology
|
||||||||
HR Double Nickase Plasmid (h) - sc-412612-NIC from Santa Cruz Biotechnology
|
||||||||
HR Double Nickase Plasmid (h2) - sc-412612-NIC-2 from Santa Cruz Biotechnology
|
||||||||
HR CRISPR Activation Plasmid (h) - sc-412612-ACT from Santa Cruz Biotechnology
|
||||||||
HR CRISPR Activation Plasmid (h2) - sc-412612-ACT-2 from Santa Cruz Biotechnology
|
||||||||
HR Lentiviral Activation Particles (h) - sc-412612-LAC from Santa Cruz Biotechnology
|
||||||||
HR Lentiviral Activation Particles (h2) - sc-412612-LAC-2 from Santa Cruz Biotechnology
|
||||||||
HR siRNA (h) - sc-77654 from Santa Cruz Biotechnology
|
||||||||
HR shRNA Plasmid (h) - sc-77654-SH from Santa Cruz Biotechnology
|
||||||||
HR shRNA (h) Lentiviral Particles - sc-77654-V from Santa Cruz Biotechnology
|
||||||||
Hairless RNAi - H00055806-R01 from Novus Biologicals
|
||||||||
Hairless RNAi - H00055806-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU059531 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN10289 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10289 from Sigma-Aldrich
|
||||||||
HR siRNA (Human) - CRJ0937 from Cohesion Biosciences
|
||||||||
HR - MBS8232392 from MyBioSource
|
||||||||
Human HR siRNA - orb271438 from Biorbyt
|
||||||||
HR shRNA Plasmid (Human) - CHJ0937 from Cohesion Biosciences
|