| Gene Symbol |
HR
|
| Entrez Gene |
55806
|
| Alt Symbol |
ALUNC, AU, HSA277165, HYPT4, MUHH, MUHH1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hair growth associated
|
| Other Description |
hairless homolog|lysine-specific demethylase hairless|protein hairless
|
| Swissprots |
Q6GS30 Q9NPE1 Q96H33 O43593
|
| Accessions |
AIW82258 AIW82259 AIW82260 AIW82261 AIW82262 EAW63716 EAW63717 EAW63718 O43593 AF039196 AAC32258 AJ277165 CAB86602 AK098053 AK308839 AL833253 AW291630 BC008946 BC067128 AAH67128 BM982749 BX109092 DA114279 DA326731 XM_005273569 XP_005273626 XM_006716367 XP_006716430 NM_005144 NP_005135 NM_018411 NP_060881
|
| Function |
Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. {ECO:0000269|PubMed:24334705}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Strongest expression of isoforms 1 and 2 is seen in the small intestine, weaker expression in brain and colon, and trace expression is found in liver, pancreas, spleen, thymus, stomach, salivary gland, appendix and trachea. Isoform 1 is always the most abundant. Isoform 1 is exclusively expressed at low levels in kidney and testis. Isoform 2 is exclusively expressed at high levels in the skin. {ECO:0000269|PubMed:10051399, ECO:0000269|PubMed:9736769}.
|