| Gene Symbol |
C1D
|
| Entrez Gene |
10438
|
| Alt Symbol |
LRP1, Rrp47, SUN-CoR, SUNCOR, hC1D
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
C1D nuclear receptor corepressor
|
| Other Description |
C1D DNA-binding protein|C1D nuclear receptor co-repressor|nuclear DNA-binding protein|nuclear nucleic acid-binding protein C1D|small unique nuclear receptor co-repressor|small unique nuclear receptor corepressor
|
| Swissprots |
Q05D64 Q13901 D6W5F8 A8K336
|
| Accessions |
AAX88887 EAW99884 EAW99885 EAW99886 Q13901 AI004680 AK290451 BAF83140 BC005235 AAH05235 BC009584 AAH09584 BC009589 AAH09589 BC016284 AAH16284 BG505686 BM354091 CN342947 DA900336 EU446867 ABZ92396 X95592 CAA64845 NM_001190263 NP_001177192 NM_001190265 NP_001177194 NM_006333 NP_006324 NM_173177 NP_775269
|
| Function |
Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Nucleus, nucleolus. Note=EXOSC10 is required for nucleolar localization.
|
| Tissue Specificity |
Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal; lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung and colon. {ECO:0000269|PubMed:10362552}.
|
| Top Pathways |
RNA degradation
|