SIRT2

Gene Symbol SIRT2
Entrez Gene 22933
Alt Symbol SIR2, SIR2L, SIR2L2
Species Human
Gene Type protein-coding
Description sirtuin 2
Other Description NAD-dependent deacetylase sirtuin-2|NAD-dependent protein deacetylase sirtuin-2|SIR2-like protein 2|regulatory protein SIR2 homolog 2|silent information regulator 2|sir2-related protein type 2|sirtuin type 2|sirtuin-2
Swissprots Q9P0G8 Q8IXJ6 U5TP13 A8K3V1 O95889 Q9UNT0 B2RB45 Q924Y7 Q9Y6E9
Accessions CAI93563 CAL00154 CAL00155 CAL48197 CAL48198 CAN36291 CAN36292 EAW56833 EAW56834 EAW56835 EAW56836 EAW56837 EAW56838 Q8IXJ6 AB009274 BAF76655 AF083107 AAD40850 AF095714 AAD45971 AF131800 AAD20046 AF160214 AAF67015 AJ505014 CAD43717 AK025876 AK054642 AK092940 AK094810 AK131390 AK225824 AK290716 BAF83405 AK314492 BAG37092 AY030277 AAK51133 BC003012 AAH03012 BC003547 AAH03547 BF346568 BF529906 DA541045 DA705079 EU447008 ABZ92537 KF032391 AGZ02589 XM_006723111 XP_006723174 XM_011526654 XP_011524956 XM_011526655 XP_011524957 XM_011526656 XP_011524958 NM_001193286 NP_001180215 NM_012237 NP_036369 NM_030593 NP_085096 NR_034146
Function Isoform 2: Deacetylates EP300, alpha-tubulin and histone H3 and H4.
Subcellular Location Isoform 2: Cytoplasm {ECO:0000269|PubMed:24177535}. Nucleus {ECO:0000269|PubMed:24177535}. Note=Predominantly localized in the cytoplasmic.
Tissue Specificity Isoform 1 is expressed in heart, liver and skeletal muscle, weakly expressed in the cortex. Isoform 2 is strongly expressed in the cortex, weakly expressed in heart and liver. Weakly expressed in several malignancies including breast, liver, brain, kidney and prostate cancers compared to normal tissues. Weakly expressed in glioma cell lines compared to normal brain tissues (at protein level). Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. {ECO:0000269|PubMed:10381378, ECO:0000269|PubMed:10393250, ECO:0000269|PubMed:12963026, ECO:0000269|PubMed:16909107, ECO:0000269|PubMed:21791548, ECO:0000269|PubMed:22014574}.

SirT2 (D4S6J) Rabbit mAb - 12672 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4S6J
Western blot analysis of extracts from SirT2 wild-type (WT) and knockout (KO) mouse brain using SirT2 (D4S6J) Rabbit mAb (upper) or GAPDH (D16H11) XP ® Rabbit mAb #5174 (lower). SirT2 WT and KO mouse brain extracts were kindly provided by Dr. Gizem Donmez, Tufts University School of Medicine.

SirT2 (D4O5O) Rabbit mAb - 12650 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4O5O
Western blot analysis of extracts from various cell lines using SirT2 (D4O5O) Rabbit mAb.

SirT2 Antibody - 2313 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

SIRT2 (A-5) - sc-28298 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SIRT2 (A-5): sc-28298 Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing cytoplasmic and membrane staining of glandular cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

SIRT2 (H-95) - sc-20966 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SIRT2 (H-95): sc-20966. Immunoperoxidase staining of formalin fixed, paraffin-embedded human breast tumor showing nuclear localization.

SIRT2 (92.259) - sc-135794 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

SIRT2 (K-15) - sc-31912 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SIRT2 (K-15): sc-31912. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoskeletal localization.

SIRT2 (36.92) - sc-135793 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-SIR2 antibody - ab106169 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT2 antibody - ab67299 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab67299 staining SIRT2 in pure rat Schwann cells by ICC/IF (Immunocytochemistry/immunofluorescence) after resveratol (RSV) treatment. Cells were fixed with 4% PFA blocked with 10% Goat serum/ 0.1% Triton x-100/ 0.1% BSA in PBS for  60 minutes at 21°C followed by 10% Goat serum/ 0.5% Triton X-100/ 0.01% BSA in PBS for 15 minutes at 21°C. Samples were incubated with primary antibody (1/100 in PBS + 10% goat serum) overnight at 21°C. An  Alexa Fluor®488-conjugated goat anti-mouse IgG polyclonal (1/400) was used as the secondary antibody. Stimulation  of rSCs with RSV led to an increase of SIRT2 expression in densitometry analysis.

Anti-SIRT2 antibody - ab19388 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SIRT2 antibody (ab19388) at 1/1000 dilution

Anti-SIRT2 antibody - ab115681 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab115681 at 5ug/ml staining SIRT2 in Human brain (cerebellum) tissue by immunohistochemistry (FFPE). Following primary incubation slides were incubated with biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-SIRT2 antibody - ab75436 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT2 antibody - ab32829 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SIRT2 antibody (ab32829) at 0.25 µg/ml + Fetal brain lysate (10ug).SecondaryHRP conjugated anti Rabbit IgG 1/50,000 - 1/100,000

Anti-SIRT2 antibody - ab169983 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human placenta tissue labeling SIRT2 with ab169983 at 1/100 dilution.

Anti-SIRT2 antibody - ab172399 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SIRT2 antibody (ab172399) at 1 µg/mlLane 1 : SIRT2 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

Anti-SIRT2 antibody - ab56904 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56904 SIR2 / SIRT2 antibody at 1ug/ml.

Anti-SIRT2 antibody [EP1668Y] - ab51023 from Abcam

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1668Y
Anti-SIRT2 antibody [EP1668Y] (ab51023) at 1/1000 dilution + SKBR-3 cell lysate at 10 µgSecondaryGoat anti-rabbit HRP labeled at 1/2000 dilution

Anti-SIRT2 antibody [EPR1667] - ab134171 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1667
All lanes : Anti-SIRT2 antibody [EPR1667] (ab134171) at 1/500 dilutionLane 1 : SKBR3 cell lysateLane 2 : SH-SY5Y cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-SIRT2 / Sirtuin 2 Antibody (aa375-389) - LS-C3189 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT2 / Sirtuin 2 Antibody - LS-C91396 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT2 / Sirtuin 2 Antibody (aa280-329) - LS-C30038 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal brain Lysate

Anti-SIRT2 / Sirtuin 2 Antibody (N-Terminus) - LS-C30926 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Fetal brain Lysate

Anti-SIRT2 / Sirtuin 2 Antibody (Internal) - LS-C144990 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT2 / Sirtuin 2 Antibody (Asp353) - LS-C193174 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Search more