| Gene Symbol |
SIRT2
|
| Entrez Gene |
22933
|
| Alt Symbol |
SIR2, SIR2L, SIR2L2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sirtuin 2
|
| Other Description |
NAD-dependent deacetylase sirtuin-2|NAD-dependent protein deacetylase sirtuin-2|SIR2-like protein 2|regulatory protein SIR2 homolog 2|silent information regulator 2|sir2-related protein type 2|sirtuin type 2|sirtuin-2
|
| Swissprots |
Q9P0G8 Q8IXJ6 U5TP13 A8K3V1 O95889 Q9UNT0 B2RB45 Q924Y7 Q9Y6E9
|
| Accessions |
CAI93563 CAL00154 CAL00155 CAL48197 CAL48198 CAN36291 CAN36292 EAW56833 EAW56834 EAW56835 EAW56836 EAW56837 EAW56838 Q8IXJ6 AB009274 BAF76655 AF083107 AAD40850 AF095714 AAD45971 AF131800 AAD20046 AF160214 AAF67015 AJ505014 CAD43717 AK025876 AK054642 AK092940 AK094810 AK131390 AK225824 AK290716 BAF83405 AK314492 BAG37092 AY030277 AAK51133 BC003012 AAH03012 BC003547 AAH03547 BF346568 BF529906 DA541045 DA705079 EU447008 ABZ92537 KF032391 AGZ02589 XM_006723111 XP_006723174 XM_011526654 XP_011524956 XM_011526655 XP_011524957 XM_011526656 XP_011524958 NM_001193286 NP_001180215 NM_012237 NP_036369 NM_030593 NP_085096 NR_034146
|
| Function |
Isoform 2: Deacetylates EP300, alpha-tubulin and histone H3 and H4.
|
| Subcellular Location |
Isoform 2: Cytoplasm {ECO:0000269|PubMed:24177535}. Nucleus {ECO:0000269|PubMed:24177535}. Note=Predominantly localized in the cytoplasmic.
|
| Tissue Specificity |
Isoform 1 is expressed in heart, liver and skeletal muscle, weakly expressed in the cortex. Isoform 2 is strongly expressed in the cortex, weakly expressed in heart and liver. Weakly expressed in several malignancies including breast, liver, brain, kidney and prostate cancers compared to normal tissues. Weakly expressed in glioma cell lines compared to normal brain tissues (at protein level). Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. {ECO:0000269|PubMed:10381378, ECO:0000269|PubMed:10393250, ECO:0000269|PubMed:12963026, ECO:0000269|PubMed:16909107, ECO:0000269|PubMed:21791548, ECO:0000269|PubMed:22014574}.
|
