SIRT2

Gene Symbol	SIRT2
Entrez Gene	22933
Alt Symbol	SIR2, SIR2L, SIR2L2
Species	Human
Gene Type	protein-coding
Description	sirtuin 2
Other Description	NAD-dependent deacetylase sirtuin-2|NAD-dependent protein deacetylase sirtuin-2|SIR2-like protein 2|regulatory protein SIR2 homolog 2|silent information regulator 2|sir2-related protein type 2|sirtuin type 2|sirtuin-2
Swissprots	Q9P0G8 Q8IXJ6 U5TP13 A8K3V1 O95889 Q9UNT0 B2RB45 Q924Y7 Q9Y6E9
Accessions	CAI93563 CAL00154 CAL00155 CAL48197 CAL48198 CAN36291 CAN36292 EAW56833 EAW56834 EAW56835 EAW56836 EAW56837 EAW56838 Q8IXJ6 AB009274 BAF76655 AF083107 AAD40850 AF095714 AAD45971 AF131800 AAD20046 AF160214 AAF67015 AJ505014 CAD43717 AK025876 AK054642 AK092940 AK094810 AK131390 AK225824 AK290716 BAF83405 AK314492 BAG37092 AY030277 AAK51133 BC003012 AAH03012 BC003547 AAH03547 BF346568 BF529906 DA541045 DA705079 EU447008 ABZ92537 KF032391 AGZ02589 XM_006723111 XP_006723174 XM_011526654 XP_011524956 XM_011526655 XP_011524957 XM_011526656 XP_011524958 NM_001193286 NP_001180215 NM_012237 NP_036369 NM_030593 NP_085096 NR_034146
Function	Isoform 2: Deacetylates EP300, alpha-tubulin and histone H3 and H4.
Subcellular Location	Isoform 2: Cytoplasm {ECO:0000269|PubMed:24177535}. Nucleus {ECO:0000269|PubMed:24177535}. Note=Predominantly localized in the cytoplasmic.
Tissue Specificity	Isoform 1 is expressed in heart, liver and skeletal muscle, weakly expressed in the cortex. Isoform 2 is strongly expressed in the cortex, weakly expressed in heart and liver. Weakly expressed in several malignancies including breast, liver, brain, kidney and prostate cancers compared to normal tissues. Weakly expressed in glioma cell lines compared to normal brain tissues (at protein level). Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. {ECO:0000269|PubMed:10381378, ECO:0000269|PubMed:10393250, ECO:0000269|PubMed:12963026, ECO:0000269|PubMed:16909107, ECO:0000269|PubMed:21791548, ECO:0000269|PubMed:22014574}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SIRT2 full length protein - ab138791 from Abcam Category Protein Prices $239.00 Sizes 20 µg Source E. coli Species Human

Active human SIRT2 full length protein - ab101132 from Abcam Category Protein Prices $302.00, $410.00 Sizes 5 µg, 10 µg Source Baculovirus Species Human

Active human SIRT2 full length protein - ab109038 from Abcam Category Protein Prices $239.00 Sizes 10 µg Source E. coli Species Human

Active human SIRT2 full length protein - ab88037 from Abcam Category Protein Prices $192.00 Sizes 25 µg Source E. coli Species Human

Active human SIRT2 protein fragment - ab79948 from Abcam Category Protein Prices $729.00 Sizes 100 µg Source E. coli Species Human

Active human SIRT2 protein fragment - ab187223 from Abcam Category Protein Prices $745.00 Sizes 50 µg Source E. coli Species Human

Human SIRT2 full length protein - ab101131 from Abcam Category Protein Source E. coli Species Human

Human SIRT2 full length protein - ab102024 from Abcam Category Protein Source E. coli Species Human

Human SIRT2 full length protein - ab169902 from Abcam Category Protein Source E. coli Species Human

SIRT2 / Sirtuin 2 Antibody Blocking Peptide - LS-E11336 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT2 / Sirtuin 2 Antibody Blocking Peptide - LS-E11335 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT2 / Sirtuin 2 Antibody Blocking Peptide - LS-E30455 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SIRT2 / Sirtuin 2 Antibody Blocking Peptide - LS-E30456 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Sirtuin 2/SIRT2 Recombinant Protein - H00022933-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Sirtuin 2/SIRT2 Partial Recombinant Protein - H00022933-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Sirtuin 2/SIRT2 Blocking Peptide - NBP1-76880PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Sirtuin 2/SIRT2 Blocking Peptide - NBP1-76879PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Sirtuin 2/SIRT2 Protein - NBP1-49460 from Novus Biologicals Category Protein Prices $309.00 Sizes 10 µg Species Human

Recombinant Human Sirtuin 2/SIRT2, CF - 4358-DA-050 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Leu51-Gln389 & Ser53-Gln389, both with a C-terminal 6-His tag

SIRT2 Protein (OPPA02620) - OPPA02620 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 1 µg Source E. Coli

Human SIRT2 protein - orb169298 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 1 μg, 5 μg, 50 μg Species Human

SIRT2 protein (His tag) - 80R-1564 from Fitzgerald Category Protein Prices $255.00 Sizes 10 µg Source E.coli

SIRT2 / SIR2 (1-352, His-tag) - AR09743PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 50 µg Source E. coli Species Human

SIRT2 / SIR2 (1-352, His-tag) - AR09743PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source E. coli Species Human

SIRT2 / SIR2 - H00022933-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

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