SIRT2

Gene Symbol SIRT2
Entrez Gene 22933
Alt Symbol SIR2, SIR2L, SIR2L2
Species Human
Gene Type protein-coding
Description sirtuin 2
Other Description NAD-dependent deacetylase sirtuin-2|NAD-dependent protein deacetylase sirtuin-2|SIR2-like protein 2|regulatory protein SIR2 homolog 2|silent information regulator 2|sir2-related protein type 2|sirtuin type 2|sirtuin-2
Swissprots Q9P0G8 Q8IXJ6 U5TP13 A8K3V1 O95889 Q9UNT0 B2RB45 Q924Y7 Q9Y6E9
Accessions CAI93563 CAL00154 CAL00155 CAL48197 CAL48198 CAN36291 CAN36292 EAW56833 EAW56834 EAW56835 EAW56836 EAW56837 EAW56838 Q8IXJ6 AB009274 BAF76655 AF083107 AAD40850 AF095714 AAD45971 AF131800 AAD20046 AF160214 AAF67015 AJ505014 CAD43717 AK025876 AK054642 AK092940 AK094810 AK131390 AK225824 AK290716 BAF83405 AK314492 BAG37092 AY030277 AAK51133 BC003012 AAH03012 BC003547 AAH03547 BF346568 BF529906 DA541045 DA705079 EU447008 ABZ92537 KF032391 AGZ02589 XM_006723111 XP_006723174 XM_011526654 XP_011524956 XM_011526655 XP_011524957 XM_011526656 XP_011524958 NM_001193286 NP_001180215 NM_012237 NP_036369 NM_030593 NP_085096 NR_034146
Function Isoform 2: Deacetylates EP300, alpha-tubulin and histone H3 and H4.
Subcellular Location Isoform 2: Cytoplasm {ECO:0000269|PubMed:24177535}. Nucleus {ECO:0000269|PubMed:24177535}. Note=Predominantly localized in the cytoplasmic.
Tissue Specificity Isoform 1 is expressed in heart, liver and skeletal muscle, weakly expressed in the cortex. Isoform 2 is strongly expressed in the cortex, weakly expressed in heart and liver. Weakly expressed in several malignancies including breast, liver, brain, kidney and prostate cancers compared to normal tissues. Weakly expressed in glioma cell lines compared to normal brain tissues (at protein level). Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. {ECO:0000269|PubMed:10381378, ECO:0000269|PubMed:10393250, ECO:0000269|PubMed:12963026, ECO:0000269|PubMed:16909107, ECO:0000269|PubMed:21791548, ECO:0000269|PubMed:22014574}.

SIRT2 CRISPR/Cas9 KO Plasmid (h) - sc-400590 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT2 HDR Plasmid (h) - sc-400590-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT2 Double Nickase Plasmid (h) - sc-400590-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT2 Double Nickase Plasmid (h2) - sc-400590-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT2 CRISPR Activation Plasmid (h) - sc-400590-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT2 CRISPR Activation Plasmid (h2) - sc-400590-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT2 Lentiviral Activation Particles (h) - sc-400590-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT2 Lentiviral Activation Particles (h2) - sc-400590-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT2 siRNA (h) - sc-40988 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SIRT2 shRNA Plasmid (h) - sc-40988-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SIRT2 shRNA (h) Lentiviral Particles - sc-40988-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sirtuin 2/SIRT2 RNAi - H00022933-R01V from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human
RNAi sequence position: Sirtuin 2/SIRT2 RNAi [H00022933-R01V]

Sirtuin 2/SIRT2 RNAi - H00022933-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU160521 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1143 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1143 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SIRT2 siRNA (Human) - CRH7884 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Sirtuin 2/SIRT2 RNAi - H00022933-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SIRT2 - MBS8234529 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SIRT2 HDR Plasmid (h2) - sc-400590-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIRT2 CRISPR/Cas9 KO Plasmid (h2) - sc-400590-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human SIRT2 (NM_012237.3) - SHH407740 from Creative biogene

Category siRNA
Species Reactivities Human

SIRT2 shRNA Plasmid (Human) - CHH7884 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SIRT2 miRNA 3'UTR clone - MiUTR3H-06841 from Creative biogene

Species Reactivities Human

SIRT2 miRNA 3'UTR clone - MiUTR3H-06842 from Creative biogene

Species Reactivities Human
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