SIRT2

Gene Symbol	SIRT2
Entrez Gene	22933
Alt Symbol	SIR2, SIR2L, SIR2L2
Species	Human
Gene Type	protein-coding
Description	sirtuin 2
Other Description	NAD-dependent deacetylase sirtuin-2|NAD-dependent protein deacetylase sirtuin-2|SIR2-like protein 2|regulatory protein SIR2 homolog 2|silent information regulator 2|sir2-related protein type 2|sirtuin type 2|sirtuin-2
Swissprots	Q9P0G8 Q8IXJ6 U5TP13 A8K3V1 O95889 Q9UNT0 B2RB45 Q924Y7 Q9Y6E9
Accessions	CAI93563 CAL00154 CAL00155 CAL48197 CAL48198 CAN36291 CAN36292 EAW56833 EAW56834 EAW56835 EAW56836 EAW56837 EAW56838 Q8IXJ6 AB009274 BAF76655 AF083107 AAD40850 AF095714 AAD45971 AF131800 AAD20046 AF160214 AAF67015 AJ505014 CAD43717 AK025876 AK054642 AK092940 AK094810 AK131390 AK225824 AK290716 BAF83405 AK314492 BAG37092 AY030277 AAK51133 BC003012 AAH03012 BC003547 AAH03547 BF346568 BF529906 DA541045 DA705079 EU447008 ABZ92537 KF032391 AGZ02589 XM_006723111 XP_006723174 XM_011526654 XP_011524956 XM_011526655 XP_011524957 XM_011526656 XP_011524958 NM_001193286 NP_001180215 NM_012237 NP_036369 NM_030593 NP_085096 NR_034146
Function	Isoform 2: Deacetylates EP300, alpha-tubulin and histone H3 and H4.
Subcellular Location	Isoform 2: Cytoplasm {ECO:0000269|PubMed:24177535}. Nucleus {ECO:0000269|PubMed:24177535}. Note=Predominantly localized in the cytoplasmic.
Tissue Specificity	Isoform 1 is expressed in heart, liver and skeletal muscle, weakly expressed in the cortex. Isoform 2 is strongly expressed in the cortex, weakly expressed in heart and liver. Weakly expressed in several malignancies including breast, liver, brain, kidney and prostate cancers compared to normal tissues. Weakly expressed in glioma cell lines compared to normal brain tissues (at protein level). Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. {ECO:0000269|PubMed:10381378, ECO:0000269|PubMed:10393250, ECO:0000269|PubMed:12963026, ECO:0000269|PubMed:16909107, ECO:0000269|PubMed:21791548, ECO:0000269|PubMed:22014574}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SIRT2 Activity Assay Kit (Fluorometric) - ab156066 from Abcam Category Cellular Assay Prices $464.00 Sizes 100 tests

SIRT2 Screening Assay Kit - ab133082 from Abcam Category Cellular Assay Prices $448.00 Sizes 96 tests

Human SIRT2 / Sirtuin 2 ELISA Kit (Sandwich ELISA) - LS-F4149 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.57 ng/ml Range 1.56-100 ng/ml

Sirtuin 2/SIRT2 Fluorometric Assay Kit - KA1368 from Novus Biologicals Category Assay Kit Prices $519.00 Sizes 1 kit

Sirtuin 2 ELISA Kit - 55R-1431 from Fitzgerald Category ELISA Kit Prices $895.00 Sizes 100 assays

NAD-dependent deacetylase sirtuin-2 (SIRT2/SIR2L/SIR2L2), Human, ELISA Kit - CSB-E17015h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

NAD-dependent deacetylase sirtuin-2, SIRT2, Human, ELISA Kit - E0430h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Sirtuin 2 (SIRT2), Human, ELISA Kit - SEA430Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.61ng/mL Range 1.56-100ng/mL

SIRT2 Direct Fluorescent Screening Assay Kit - KA1368 from Acris Antibodies Category ELISA Kit Prices $470.00 Sizes 1 kit

Human Sirtuin 2 ELISA Kit - 68ELH-Sirtuin2 from RayBiotech Category ELISA Kit

sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) , ELISA Kit - MBS705927 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human SIRT2 is typically less than 0.78 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 3.12 pg/ml-200 pg/ml.

Sirtuin 2 (human intracellular) ELISA Kit - GWB-AXR259 from Genway Biotech Category ELISA Kit Prices $1,444.00 Sizes 100 assays

Human Sirtuin 2 ELISA KIT - DEIA7480 from Creative Diagnostics Category ELISA Kit

Sirtuin 2 (human intracellular) ELISA Kit - DEIA8615 from Creative Diagnostics Category ELISA Kit

Sirtuin 2, ELISA Kit - MBS098564 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sirtuin 2, ELISA Kit - MBS057348 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sirtuin 2, ELISA Kit - MBS074282 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sirtuin 2, ELISA Kit - MBS076909 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/ml. Range 3.12 ng/ml - 100 ng/ml.

Sirtuin 2, ELISA Kit - MBS079487 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.25ng/ml-8ng/ml.

Sirtuin 2, ELISA Kit - MBS108260 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sirtuin 2, ELISA Kit - MBS055544 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Sirtuin 2 (SIRT2) - SEA430Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.55ng/mL. Range 1.56-100ng/mL The standard curve concentrations used for the ELISA’s were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.13ng/mL, 1.56ng/mL

ELISA Kit for Sirtuin 2 (SIRT2) - SEA430Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.54ng/mL. Range 1.56-100ng/mL The standard curve concentrations used for the ELISA’s were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.13ng/mL, 1.56ng/mL

Human NAD-dependent deacetylase sirtuin-2 (SIRT2/SIR2L/SIR2L2) ELISA kit - CSB-E17015h from Cusabio Category ELISA Kit Sensitivity 0.78 pg/ml. Range Request Information

ELISA Kit for Sirtuin 2 (SIRT2) - SEA430Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.55ng/mL. Range 1.563-100ng/mL The standard curve concentrations used for the ELISA's were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL

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