CLDN16

Gene Symbol	CLDN16
Entrez Gene	10686
Alt Symbol	HOMG3, PCLN1
Species	Human
Gene Type	protein-coding
Description	claudin 16
Other Description	PCLN-1\|claudin-16\|hypomagnesemia 3, with hypercalciuria and nephrocalcinosis\|paracellin-1
Swissprots	Q9Y5I7
Accessions	EAW78106 Q9Y5I7 AF152101 AAD43096 AK314955 BC069662 AAH69662 BC069682 AAH69682 BC069759 AAH69759 BC069777 AAH69777 BF034334 CB241927 DQ305102 ABC47832 HQ448426 ADQ32906 NM_006580 NP_006571
Function	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.
Subcellular Location	Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Kidney-specific, including the thick ascending limb of Henle (TAL).
Top Pathways	Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Hepatitis C

PCLN-1 (7A2) - sc-130561 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

PCLN-1 (7A2): sc-130561. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.

PCLN-1 (K-14) - sc-10179 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

PCLN-1 (K-14): sc-10179. Western blot analysis of PCLN-1 expression in Hep G2 whole cell lysate.

PCLN-1 (P-14) - sc-10178 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

PCLN-1 (D-23) - sc-133893 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	50 µg/0.5 ml
Host	Rabbit
Clonality	Polyclonal

PCLN-1 (D-23): sc-133893. Western blot analysis of PCLN-1 expression in human fetal lung tissue extract.

Anti-CLDN16 antibody - ab106504 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-CLDN16 antibody (ab106504) at 1 µg/mlLane 1 : Kidney (Human) Tissue Lysate - adult normal tissue (ab30203)Lane 2 : Kidney (Human) Tissue Lysate - fetal normal tissue (ab30204)Lane 3 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CLDN16 antibody - ab107041 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CLDN16 antibody (ab107041) at 1/100 dilution + MDA-MB435 cell lysate at 35 µg

Anti-CLDN16 antibody [4C10] - BSA free - ab180831 from Abcam

Host	Mouse
Clonality	Monoclonal
Clone	4C10

Anti-CLDN16 / Claudin 16 Antibody (C-Terminus) - LS-C6172 from LifeSpan Bioscience

Prices	$515.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CLDN16 / Claudin 16 Antibody - LS-C6173 from LifeSpan Bioscience

Prices	$385.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CLDN16 / Claudin 16 Antibody (aa13-41, APC) - LS-C221800 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CLDN16 / Claudin 16 Antibody (aa13-41, AP) - LS-C221799 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CLDN16 / Claudin 16 Antibody (aa13-41, Biotin) - LS-C221801 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CLDN16 / Claudin 16 Antibody (aa13-41, FITC) - LS-C221802 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CLDN16 / Claudin 16 Antibody (aa13-41, Azide-free, HRP) - LS-C221803 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CLDN16 / Claudin 16 Antibody (aa13-41, PE) - LS-C221804 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CLDN16 / Claudin 16 Antibody (C-Terminus) - LS-C30415 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CLDN16 / Claudin 16 Antibody (aa13-41) - LS-C320420 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CLDN16 / Claudin 16 Antibody (aa1-73) - LS-C306974 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-CLDN16 / Claudin 16 Antibody (C-Terminus) - LS-C30740 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CLDN16 / Claudin 16 Antibody (aa6-33) IHC-plus™ - LS-B10372 from LifeSpan Bioscience

Prices	$395.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CLDN16 / Claudin 16 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Claudin-16 Antibody - NBP1-59105 from Novus Biologicals

Prices	$139.00, $299.00
Sizes	20 µl, 100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: Claudin 16 Antibody [NBP1-59105] - Human Fetal kidney Lysate, concentration 1.25 ug/ml.

Claudin-16 Antibody - NBP2-38777 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry: Claudin-16 Antibody [NBP2-38777] - Staining of human kidney shows strong cytoplasmic and membranous positivity in subset of cells in tubules.

Claudin-16 Antibody - H00010686-A01 from Novus Biologicals

Prices	$269.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Western Blot: Claudin 16 Antibody [H00010686-A01] - Western Blot analysis of CLDN16 expression in Daoy.

Claudin-16 Antibody (1F2) - H00010686-M02 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	1F2

Claudin 16 Polyclonal Antibody - bs-13752R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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