CLDN16

Gene Symbol	CLDN16
Entrez Gene	10686
Alt Symbol	HOMG3, PCLN1
Species	Human
Gene Type	protein-coding
Description	claudin 16
Other Description	PCLN-1|claudin-16|hypomagnesemia 3, with hypercalciuria and nephrocalcinosis|paracellin-1
Swissprots	Q9Y5I7
Accessions	EAW78106 Q9Y5I7 AF152101 AAD43096 AK314955 BC069662 AAH69662 BC069682 AAH69682 BC069759 AAH69759 BC069777 AAH69777 BF034334 CB241927 DQ305102 ABC47832 HQ448426 ADQ32906 NM_006580 NP_006571
Function	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.
Subcellular Location	Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Kidney-specific, including the thick ascending limb of Henle (TAL).
Top Pathways	Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Hepatitis C

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CLDN16 full length protein - ab161109 from Abcam Category Protein Source Wheat germ Species Human

Human CLDN16 protein fragment - ab161110 from Abcam Category Protein Source Wheat germ Species Human

CLDN16 / Claudin 16 Antibody Blocking Peptide - LS-E209 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLDN16 / Claudin 16 Antibody Blocking Peptide - LS-E11896 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Claudin-16 Protein - H00010686-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human Claudin-16 Protein - H00010686-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CLDN16-Antibody-N-term-Blocking-peptide - BP10435a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Claudin-16 / CLDN16 - H00010686-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

Claudin-16 / CLDN16 - H00010686-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Claudin-16 / CLDN16 - H00010686-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CLDN16 fusion protein - ag14929 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human CLDN16, GST-tagged - CLDN16-11288H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Claudin 16 (CLDN16) - RPF296Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Claudin-16 Recombinant Protein Antigen - NBP2-38777PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CLDN16 Peptide, Human - M34GP03229H from Creative Peptides Category Peptide Source Synthetic. Species Human

CLDN16 fusion protein - Ag26531 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

CLDN16 fusion protein - Ag26554 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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