| Gene Symbol |
CLDN16
|
| Entrez Gene |
10686
|
| Alt Symbol |
HOMG3, PCLN1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
claudin 16
|
| Other Description |
PCLN-1|claudin-16|hypomagnesemia 3, with hypercalciuria and nephrocalcinosis|paracellin-1
|
| Swissprots |
Q9Y5I7
|
| Accessions |
EAW78106 Q9Y5I7 AF152101 AAD43096 AK314955 BC069662 AAH69662 BC069682 AAH69682 BC069759 AAH69759 BC069777 AAH69777 BF034334 CB241927 DQ305102 ABC47832 HQ448426 ADQ32906 NM_006580 NP_006571
|
| Function |
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.
|
| Subcellular Location |
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Kidney-specific, including the thick ascending limb of Henle (TAL).
|
| Top Pathways |
Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Hepatitis C
|