CLDN16

Gene Symbol CLDN16
Entrez Gene 10686
Alt Symbol HOMG3, PCLN1
Species Human
Gene Type protein-coding
Description claudin 16
Other Description PCLN-1|claudin-16|hypomagnesemia 3, with hypercalciuria and nephrocalcinosis|paracellin-1
Swissprots Q9Y5I7
Accessions EAW78106 Q9Y5I7 AF152101 AAD43096 AK314955 BC069662 AAH69662 BC069682 AAH69682 BC069759 AAH69759 BC069777 AAH69777 BF034334 CB241927 DQ305102 ABC47832 HQ448426 ADQ32906 NM_006580 NP_006571
Function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.
Subcellular Location Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Tissue Specificity Kidney-specific, including the thick ascending limb of Henle (TAL).
Top Pathways Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Hepatitis C

PCLN-1 CRISPR/Cas9 KO Plasmid (h) - sc-405445 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCLN-1 HDR Plasmid (h) - sc-405445-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCLN-1 Double Nickase Plasmid (h) - sc-405445-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCLN-1 Double Nickase Plasmid (h2) - sc-405445-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCLN-1 CRISPR Activation Plasmid (h) - sc-405445-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCLN-1 CRISPR Activation Plasmid (h2) - sc-405445-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCLN-1 Lentiviral Activation Particles (h) - sc-405445-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCLN-1 Lentiviral Activation Particles (h2) - sc-405445-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCLN-1 siRNA (h) - sc-42588 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PCLN-1 shRNA Plasmid (h) - sc-42588-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PCLN-1 shRNA (h) Lentiviral Particles - sc-42588-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU027551 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6177 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6177 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CLDN16 siRNA (Human) - CRH7287 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Claudin-16 RNAi - H00010686-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CLDN16 - MBS8224151 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CLDN16 (NM_006580.3) - SHH264693 from Creative biogene

Category siRNA
Species Reactivities Human

CLDN16 shRNA Plasmid (Human) - CHH7287 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CLDN16 miRNA 3'UTR clone - MiUTR4H-TG02149 from Creative biogene

Species Reactivities Human
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