PRF1

Gene Symbol	PRF1
Entrez Gene	5551
Alt Symbol	FLH2, HPLH2, P1, PFN1, PFP
Species	Human
Gene Type	protein-coding
Description	perforin 1 (pore forming protein)
Other Description	cytolysin|lymphocyte pore forming protein|lymphocyte pore-forming protein|perforin-1
Swissprots	Q59F57 Q86WX7 P14222 B2R6X4
Accessions	AAA60167 AGS13731 AGS13732 AHC72295 AHC72296 EAW54407 P14222 AB209604 BAD92841 AK312754 BAG35621 BC047695 AAH47695 BC063043 AAH63043 BQ051559 BQ654088 DA816891 DA941244 FJ555237 ACU25794 L40557 AAA63618 M28393 AAA60065 X13224 CAA31612 NM_001083116 NP_001076585 NM_005041 NP_005032
Function	Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. {ECO:0000269|PubMed:20038786, ECO:0000269|PubMed:20225066, ECO:0000269|PubMed:20889983, ECO:0000269|PubMed:21037563, ECO:0000269|PubMed:9058810, ECO:0000269|PubMed:9164947}.
Subcellular Location	Cytoplasmic granule lumen. Secreted. Cell membrane; Multi-pass membrane protein. Endosome lumen. Note=Stored in cytoplasmic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell. Inserts into the cell membrane of target cells and forms pores. Membrane insertion and pore formation requires a major conformation change. May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes.
Top Pathways	Natural killer cell mediated cytotoxicity, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Type I diabetes mellitus

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PRF1 293T Cell Transient Overexpression Lysate(Denatured) - H00005551-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

PRF1 overexpression lysate - LY417566 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PRF1 overexpression lysate - LY421209 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PRF1 293 Cell Lysate - 408218 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Perforin Overexpression Lysate (Denatured) - H00005551-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Perforin Overexpression Lysate (Native) - NBL1-14750 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Perforin 1 (h): 293T Lysate - sc-116672 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

PRF1 Over-expression Lysate Product - GWB-14AF9C from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Perforin Overexpression Lysate (Native) - NBP2-10656 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Perforin Overexpression Lysate (Denatured) - H00005551-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human PRF1 Knockdown Stable Cell Line - CSC-DC012373 from Creative biogene Category Cell Line Species Human

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