PRF1

Gene Symbol	PRF1
Entrez Gene	5551
Alt Symbol	FLH2, HPLH2, P1, PFN1, PFP
Species	Human
Gene Type	protein-coding
Description	perforin 1 (pore forming protein)
Other Description	cytolysin|lymphocyte pore forming protein|lymphocyte pore-forming protein|perforin-1
Swissprots	Q59F57 Q86WX7 P14222 B2R6X4
Accessions	AAA60167 AGS13731 AGS13732 AHC72295 AHC72296 EAW54407 P14222 AB209604 BAD92841 AK312754 BAG35621 BC047695 AAH47695 BC063043 AAH63043 BQ051559 BQ654088 DA816891 DA941244 FJ555237 ACU25794 L40557 AAA63618 M28393 AAA60065 X13224 CAA31612 NM_001083116 NP_001076585 NM_005041 NP_005032
Function	Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. {ECO:0000269|PubMed:20038786, ECO:0000269|PubMed:20225066, ECO:0000269|PubMed:20889983, ECO:0000269|PubMed:21037563, ECO:0000269|PubMed:9058810, ECO:0000269|PubMed:9164947}.
Subcellular Location	Cytoplasmic granule lumen. Secreted. Cell membrane; Multi-pass membrane protein. Endosome lumen. Note=Stored in cytoplasmic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell. Inserts into the cell membrane of target cells and forms pores. Membrane insertion and pore formation requires a major conformation change. May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes.
Top Pathways	Natural killer cell mediated cytotoxicity, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Type I diabetes mellitus

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Perforin full length protein - ab114201 from Abcam Category Protein Source Wheat germ Species Human

Human Perforin peptide - ab99163 from Abcam Category Peptide

Human Perforin protein fragment - ab112345 from Abcam Category Protein Source Wheat germ Species Human

Recombinant rat Perforin-1 (OPCA00189) - OPCA00189 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Rat

Human PRF1 protein - orb244457 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Perforin 1 Blocking Peptide - 33R-8899 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human Perforin 1 Protein - abx068462 from Abbexa Category Protein Source E.coli Species Human

Perforin 1 / PRF1 - H00005551-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Perforin 1 / PRF1 - H00005551-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Perforin 1 / PRF1 - H00005551-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Perforin 1 / PRF1 - H00005551-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Recombinant Human Perforin-1 - 230-00687-10 from RayBiotech Category Protein Prices $110.00 Sizes 10 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human Perforin-1 - 230-00687-50 from RayBiotech Category Protein Prices $220.00 Sizes 50 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human Perforin-1 - 230-00687-100 from RayBiotech Category Protein Prices $308.00 Sizes 100 µg Source Escherichia coli (E.coli) Species Human

Perforin 1 (PRF1), Human - 20-7639 from ARP American Research Products Category Protein Prices $669.00 Sizes 50 µg Source E.coli Species Human

Perforin fusion protein - Ag6060 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human PRF1 - PRF1-29996TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human PRF1 - PRF1-30288TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human PRF1, His-tagged - PRF1-1942H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human PRF1 - PRF1-326H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Native Human Perforin - PRF1-55H from Creative Biomart Category Protein Source Human cytotoxic granules of YT cells. Species Human

Recombinant Perforin 1 (PRF1) - RPB317Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Perforin 1 (PRF1) - RPB317Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Perforin 1 (PRF1) - RPB317Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Perforin 1 (PRF1) - RPB317Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

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