ELK4

Gene Symbol	ELK4
Entrez Gene	2005
Alt Symbol	SAP1
Species	Human
Gene Type	protein-coding
Description	ELK4, ETS-domain protein (SRF accessory protein 1)
Other Description	ETS domain-containing protein Elk-4|SAP-1|serum response factor accessory protein 1
Swissprots	P28324 P28323 Q6GSJ2
Accessions	CCV01469 CCV01470 EAW91570 EAW91571 EAW91572 EAW91573 EAW91574 P28324 AF075044 AI002107 AI005122 AK024944 AL117645 BC040145 AAH40145 BC063676 AAH63676 BE041598 BE675475 BE676052 BF433322 BX346360 EU446469 ABZ91998 M85164 AAA03632 M85165 AAA03631 T27937 XM_005244950 XP_005245007 XM_005244951 XP_005245008 XR_426764 XR_426766 XR_921752 XR_921753 NM_001973 NP_001964 NM_021795 NP_068567
Function	Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. {ECO:0000269|PubMed:22722849}.
Subcellular Location	Nucleus.
Top Pathways	MAPK signaling pathway, HTLV-I infection, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SAP-1 CRISPR/Cas9 KO Plasmid (h) - sc-403868 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SAP-1 HDR Plasmid (h) - sc-403868-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SAP-1 Double Nickase Plasmid (h) - sc-403868-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SAP-1 Double Nickase Plasmid (h2) - sc-403868-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SAP-1 CRISPR Activation Plasmid (h) - sc-403868-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SAP-1 CRISPR Activation Plasmid (h2) - sc-403868-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SAP-1 Lentiviral Activation Particles (h) - sc-403868-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SAP-1 Lentiviral Activation Particles (h2) - sc-403868-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SAP-1 siRNA (h) - sc-77346 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SAP-1 shRNA Plasmid (h) - sc-77346-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SAP-1 shRNA (h) Lentiviral Particles - sc-77346-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ELK4 RNAi - H00002005-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

ELK4 RNAi - H00002005-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU067461 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7808 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7808 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04899 from Sigma-Aldrich Category miRNA

ELK4 siRNA (Human) - CRH1388 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ELK4 - MBS8237481 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human ELK4 (NM_001973.3) - SHH285101 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human ELK4(NM_021795.2) - SHH031439 from Creative biogene Category siRNA Species Reactivities Human

Human ELK4 siRNA - orb261890 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ELK4 shRNA Plasmid (Human) - CHH1388 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

ELK4 miRNA 3'UTR clone - MiUTR1H-03195 from Creative biogene Species Reactivities Human

ELK4 miRNA 3'UTR clone - MiUTR3H-03216 from Creative biogene Species Reactivities Human

Search more