ELK4

Gene Symbol	ELK4
Entrez Gene	2005
Alt Symbol	SAP1
Species	Human
Gene Type	protein-coding
Description	ELK4, ETS-domain protein (SRF accessory protein 1)
Other Description	ETS domain-containing protein Elk-4|SAP-1|serum response factor accessory protein 1
Swissprots	P28324 P28323 Q6GSJ2
Accessions	CCV01469 CCV01470 EAW91570 EAW91571 EAW91572 EAW91573 EAW91574 P28324 AF075044 AI002107 AI005122 AK024944 AL117645 BC040145 AAH40145 BC063676 AAH63676 BE041598 BE675475 BE676052 BF433322 BX346360 EU446469 ABZ91998 M85164 AAA03632 M85165 AAA03631 T27937 XM_005244950 XP_005245007 XM_005244951 XP_005245008 XR_426764 XR_426766 XR_921752 XR_921753 NM_001973 NP_001964 NM_021795 NP_068567
Function	Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. {ECO:0000269|PubMed:22722849}.
Subcellular Location	Nucleus.
Top Pathways	MAPK signaling pathway, HTLV-I infection, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ELK4 full length protein - ab158353 from Abcam Category Protein Source Wheat germ Species Human

Human ELK4 protein fragment - ab114409 from Abcam Category Protein Source Wheat germ Species Human

ELK4 Antibody Blocking Peptide - LS-E12244 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ELK4 Antibody Blocking Peptide - LS-E25162 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ELK4 Protein - H00002005-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ELK4 Protein - H00002005-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

SAP-1 peptide - orb73184 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

ELK4 - H00002005-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

ELK4 - H00002005-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ELK4 - H00002005-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ELK4 fusion protein - ag7006 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

ELK4 fusion protein - ag6273 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human ELK4 - ELK4-28290TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human ETS domain-containing protein Elk-4(ELK4) - CSB-YP007607HU CSB-EP007607HU CSB-BP007607HU CSB-MP007607HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ELK4 (transcript variant b) - TP309572 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

ELK4 (full length, N-term HIS tag, transcript variant a) - TP760364 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

ELK4 Recombinant Protein Antigen - NBP1-87092PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ELK4-Antibody-Center-Blocking-peptide - BP10034c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ELK4 Peptide, Human - M34GP04862H from Creative Peptides Category Peptide Source Synthetic. Species Human

ETS domain-containing protein Elk-4 (ELK4), Recombinant Protein - MBS968475 from MyBioSource Category Protein Prices $1,210.00, $1,210.00, $1,425.00, $1,425.00, $1,950.00, $1,950.00, $2,415.00, $2,415.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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