Gene Symbol | UBE2E3 |
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Entrez Gene | 10477 |
Alt Symbol | UBCH9, UbcM2 |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin-conjugating enzyme E2E 3 |
Other Description | ubiquitin carrier protein E3|ubiquitin-conjugating enzyme E2 E3|ubiquitin-conjugating enzyme E2-23 kDa|ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)|ubiquitin-conjugating enzyme E2E 3 (homologous to yeast UBC4/5)|ubiquitin-protein ligase E3 |
Swissprots | Q7Z4W4 B2RAD6 Q969T4 Q5U0R7 D3DPG3 |
Accessions | AAY14882 EAX10989 EAX10990 Q969T4 AB017644 BAA76544 AF085362 AAD40197 AK314145 BAG36833 BC003554 AAH03554 BC003687 BC092407 AAH92407 BI257596 BM762761 BQ932163 BT019345 AAV38152 BU608985 CN369618 DA568152 DB458228 XM_005246244 XP_005246301 XM_011510492 XP_011508794 NM_001278554 NP_001265483 NM_001278555 NP_001265484 NM_006357 NP_006348 NM_182678 NP_872619 |
Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest. {ECO:0000269|PubMed:10343118, ECO:0000269|PubMed:20061386}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15545318}. Cytoplasm {ECO:0000269|PubMed:15545318}. Note=Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner. |
Tissue Specificity | Ubiquitously expressed at low levels. Highly expressed in skeletal muscle. {ECO:0000269|PubMed:10343118}. |
Top Pathways | Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum |
UBE2E3 (N-15) - sc-50868 from Santa Cruz Biotechnology
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Anti-UBE2E3 antibody - ab71639 from Abcam
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Anti-UBE2E3 antibody [4B4] - ab128098 from Abcam
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Anti-UBE2E3 antibody - N-terminal - ab71640 from Abcam
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Anti-UBE2E3 Antibody (clone 7E8) - LS-C336916 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (clone 1D10) - LS-C173914 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (clone 1D12) - LS-C173910 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (clone 2B1) - LS-C173911 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (clone 3F7) - LS-C175113 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (clone GF1) - LS-C190158 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (N-Terminus, AP) - LS-C220981 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (N-Terminus, APC) - LS-C220982 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (N-Terminus, Azide-free, HRP) - LS-C220983 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (N-Terminus, Biotin) - LS-C220984 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (N-Terminus, PE) - LS-C220986 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (N-Terminus, FITC) - LS-C220985 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (C-Terminus, AP) - LS-C220987 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (clone 3E5) - LS-C175103 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (C-Terminus, APC) - LS-C220988 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (C-Terminus, Biotin) - LS-C220989 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (C-Terminus, FITC) - LS-C220990 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (C-Terminus, PE) - LS-C220992 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (C-Terminus, Azide-free, HRP) - LS-C220993 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (clone 2C7) - LS-C175115 from LifeSpan Bioscience
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Anti-UBE2E3 Antibody (N-Terminus) - LS-C328991 from LifeSpan Bioscience
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