| Gene Symbol |
UBE2E3
|
| Entrez Gene |
10477
|
| Alt Symbol |
UBCH9, UbcM2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2E 3
|
| Other Description |
ubiquitin carrier protein E3|ubiquitin-conjugating enzyme E2 E3|ubiquitin-conjugating enzyme E2-23 kDa|ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)|ubiquitin-conjugating enzyme E2E 3 (homologous to yeast UBC4/5)|ubiquitin-protein ligase E3
|
| Swissprots |
Q7Z4W4 B2RAD6 Q969T4 Q5U0R7 D3DPG3
|
| Accessions |
AAY14882 EAX10989 EAX10990 Q969T4 AB017644 BAA76544 AF085362 AAD40197 AK314145 BAG36833 BC003554 AAH03554 BC003687 BC092407 AAH92407 BI257596 BM762761 BQ932163 BT019345 AAV38152 BU608985 CN369618 DA568152 DB458228 XM_005246244 XP_005246301 XM_011510492 XP_011508794 NM_001278554 NP_001265483 NM_001278555 NP_001265484 NM_006357 NP_006348 NM_182678 NP_872619
|
| Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest. {ECO:0000269|PubMed:10343118, ECO:0000269|PubMed:20061386}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15545318}. Cytoplasm {ECO:0000269|PubMed:15545318}. Note=Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner.
|
| Tissue Specificity |
Ubiquitously expressed at low levels. Highly expressed in skeletal muscle. {ECO:0000269|PubMed:10343118}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum
|