TYROBP

Gene Symbol	TYROBP
Entrez Gene	7305
Alt Symbol	DAP12, KARAP, PLOSL
Species	Human
Gene Type	protein-coding
Description	TYRO protein tyrosine kinase binding protein
Other Description	DNAX-activation protein 12|KAR-associated protein|TYRO protein tyrosine kinase-binding protein|killer-activating receptor-associated protein
Swissprots	A8K2X0 O43914 Q6FGA5 Q9UMT3 F5H389
Accessions	AAD09437 O43914 AF019562 AAD09436 AJ010098 CAB52288 AK290385 BAF83074 AY074782 AAL74017 BC011175 AAH11175 BI908458 BP295666 BP302545 BP305672 BQ576278 BT009851 AAP88853 CR450342 CAG29338 CR542202 CAG46999 DQ891092 ABM82018 DQ894274 ABM85200 NM_001173514 NP_001166985 NM_001173515 NP_001166986 NM_003332 NP_003323 NM_198125 NP_937758 NR_033390
Function	Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum. {ECO:0000269|PubMed:11922939}.
Top Pathways	Natural killer cell mediated cytotoxicity, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TYRO protein tyrosine kinase-binding protein (TYROBP), Human, ELISA Kit - CSB-EL025398HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

TYRO protein tyrosine kinase-binding protein, TYROBP, Human, ELISA Kit - E12665h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

TYRO protein tyrosine kinase binding protein, ELISA Kit - MBS904692 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

TYRO Protein Tyrosine Kinase Binding Protein (TYROBP), ELISA Kit - MBS2024904 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.053ng/mL. Range 0.156-10ng/mL

ELISA Kit for TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) - SEG524Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.053ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human TYRO protein tyrosine kinase-binding protein(TYROBP) ELISA kit - CSB-EL025398HU from Cusabio Category ELISA Kit Sensitivity 3.9pg/ml Range 15.6 pg/ml-1000 pg/ml

ELISA Kit for TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) - SEG524Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.053ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Rat DAP12 ELISA Kit (Custom ELISA) - LS-F16684 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Pig DAP12 ELISA Kit (Custom ELISA) - LS-F16681 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse DAP12 ELISA Kit (Competitive EIA) - LS-F16682 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.31 ng/ml Range 0.156-10 ng/ml

Bovine DAP12 ELISA Kit (Custom ELISA) - LS-F16683 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human DAP12 ELISA Kit (Sandwich ELISA) - LS-F13489 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Human DAP12 ELISA Kit (Sandwich ELISA) - LS-F25514 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.053 ng/ml Range 0.156-10 ng/ml

TYROBP - EKH2888 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

TYROBP ELISA Kit (Human) : 96 Wells (OKEH02258) - OKEH02258 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.056 ng/mL Range 0.156 - 10 ng/mL

Human TYROBP ELISA Kit - E040113 from Biobool Category ELISA Kit Sensitivity 3.9 pg/ml

Human TYRO protein tyrosine kinase-binding protein ELISA Kit - EK3096 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.056ng/ml Range 0.156-10 ng/mL

Human TYRO protein tyrosine kinase-binding protein (TYROBP) ELISA Kit - AE12639HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.053 ng/mL Range 0.156-10 ng/mL

TYRO protein tyrosine kinase-binding protein, ELISA Kit - MBS764281 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/ml Range 0.156-10ng/ml

TYRO protein tyrosine kinase-binding protein, ELISA Kit - MBS2886582 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.156-10 ng/mL

TYRO protein tyrosine kinase-binding protein, ELISA Kit - MBS9426930 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 0.056ng/mL Range 0.156-10 ng/mL

Human DAP12 ELISA Kit (Sandwich ELISA) - LS-F35786 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.094 Range 0.156-10 ng/ml

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