TYROBP

Gene Symbol TYROBP
Entrez Gene 7305
Alt Symbol DAP12, KARAP, PLOSL
Species Human
Gene Type protein-coding
Description TYRO protein tyrosine kinase binding protein
Other Description DNAX-activation protein 12|KAR-associated protein|TYRO protein tyrosine kinase-binding protein|killer-activating receptor-associated protein
Swissprots A8K2X0 O43914 Q6FGA5 Q9UMT3 F5H389
Accessions AAD09437 O43914 AF019562 AAD09436 AJ010098 CAB52288 AK290385 BAF83074 AY074782 AAL74017 BC011175 AAH11175 BI908458 BP295666 BP302545 BP305672 BQ576278 BT009851 AAP88853 CR450342 CAG29338 CR542202 CAG46999 DQ891092 ABM82018 DQ894274 ABM85200 NM_001173514 NP_001166985 NM_001173515 NP_001166986 NM_003332 NP_003323 NM_198125 NP_937758 NR_033390
Function Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum. {ECO:0000269|PubMed:11922939}.
Top Pathways Natural killer cell mediated cytotoxicity, Osteoclast differentiation

DAP12 CRISPR/Cas9 KO Plasmid (h) - sc-400916 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DAP12 HDR Plasmid (h) - sc-400916-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DAP12 Double Nickase Plasmid (h) - sc-400916-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DAP12 Double Nickase Plasmid (h2) - sc-400916-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DAP12 CRISPR Activation Plasmid (h) - sc-400916-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DAP12 CRISPR Activation Plasmid (h2) - sc-400916-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DAP12 Lentiviral Activation Particles (h) - sc-400916-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DAP12 Lentiviral Activation Particles (h2) - sc-400916-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DAP12 siRNA (h) - sc-35172 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DAP12 shRNA Plasmid (h) - sc-35172-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DAP12 shRNA (h) Lentiviral Particles - sc-35172-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU033221 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22324 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22324 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01264 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01264

TYROBP siRNA (Human) - CRH4995 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TYROBP - MBS827692 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TYROBP (NM_003332.3) - SHH438468 from Creative biogene

Category siRNA
Species Reactivities Human

TYROBP shRNA Plasmid (Human) - CHH4995 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TYROBP miRNA 3'UTR clone - MiUTR3H-06591 from Creative biogene

Species Reactivities Human

TYROBP miRNA 3'UTR clone - MiUTR3H-06592 from Creative biogene

Species Reactivities Human
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