TYROBP

Gene Symbol	TYROBP
Entrez Gene	7305
Alt Symbol	DAP12, KARAP, PLOSL
Species	Human
Gene Type	protein-coding
Description	TYRO protein tyrosine kinase binding protein
Other Description	DNAX-activation protein 12|KAR-associated protein|TYRO protein tyrosine kinase-binding protein|killer-activating receptor-associated protein
Swissprots	A8K2X0 O43914 Q6FGA5 Q9UMT3 F5H389
Accessions	AAD09437 O43914 AF019562 AAD09436 AJ010098 CAB52288 AK290385 BAF83074 AY074782 AAL74017 BC011175 AAH11175 BI908458 BP295666 BP302545 BP305672 BQ576278 BT009851 AAP88853 CR450342 CAG29338 CR542202 CAG46999 DQ891092 ABM82018 DQ894274 ABM85200 NM_001173514 NP_001166985 NM_001173515 NP_001166986 NM_003332 NP_003323 NM_198125 NP_937758 NR_033390
Function	Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum. {ECO:0000269|PubMed:11922939}.
Top Pathways	Natural killer cell mediated cytotoxicity, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TYROBP-Over-expression-Lysate - LY13304a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

TYROBP overexpression lysate - LY403671 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

TYROBP overexpression lysate - LY418750 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

TYROBP 293 Cell Lysate - 403164 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

TYROBP 293 Cell Lysate - 408756 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

DAP12 Overexpression Lysate (Native) - NBL1-17483 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

DAP12 Overexpression Lysate (Native) - NBL1-17484 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

DAP12 (h): 293T Lysate - sc-112269 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

DAP12 (h2): 293T Lysate - sc-174294 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

DAP12 (h3): 293T Lysate - sc-174316 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

TYROBP Over-expression Lysate Product - GWB-F85720 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

TYROBP Over-expression Lysate Product - GWB-DDB2A0 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Panoply™ Human TYROBP Knockdown Stable Cell Line - CSC-DC016915 from Creative biogene Category Cell Line Species Human

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