TYROBP

Gene Symbol	TYROBP
Entrez Gene	7305
Alt Symbol	DAP12, KARAP, PLOSL
Species	Human
Gene Type	protein-coding
Description	TYRO protein tyrosine kinase binding protein
Other Description	DNAX-activation protein 12|KAR-associated protein|TYRO protein tyrosine kinase-binding protein|killer-activating receptor-associated protein
Swissprots	A8K2X0 O43914 Q6FGA5 Q9UMT3 F5H389
Accessions	AAD09437 O43914 AF019562 AAD09436 AJ010098 CAB52288 AK290385 BAF83074 AY074782 AAL74017 BC011175 AAH11175 BI908458 BP295666 BP302545 BP305672 BQ576278 BT009851 AAP88853 CR450342 CAG29338 CR542202 CAG46999 DQ891092 ABM82018 DQ894274 ABM85200 NM_001173514 NP_001166985 NM_001173515 NP_001166986 NM_003332 NP_003323 NM_198125 NP_937758 NR_033390
Function	Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum. {ECO:0000269|PubMed:11922939}.
Top Pathways	Natural killer cell mediated cytotoxicity, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DAP12 peptide - ab107906 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human DAP12 full length protein - ab132176 from Abcam Category Protein Source Wheat germ Species Human

Human DAP12 full length protein - ab152777 from Abcam Category Protein Source Wheat germ Species Human

DAP12 Antibody Blocking Peptide - LS-E27027 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DAP12 Antibody Blocking Peptide - LS-E10359 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DAP12 Protein - H00007305-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human DAP12 Protein - H00007305-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TYROBP-Antibody-C-term-Blocking-Peptide - BP9862b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TYROBP Protein Lysate (APL10362) - APL10362 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

TYROBP Protein Lysate (APL10501) - APL10501 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

DAP12 Blocking Peptide - 33R-11048 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

TYROBP / DAP12 - H00007305-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TYROBP / DAP12 - H00007305-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TYROBP / DAP12 - H00007305-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TYROBP / DAP12 - H00007305-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) - RPG524Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) - RPG524Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human TYRO protein tyrosine kinase-binding protein(TYROBP) - CSB-YP025398HU CSB-EP025398HU CSB-BP025398HU CSB-MP025398HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DAP12 Blocking Peptide - 5570RBP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

TYROBP / DAP12 (transcript variant 1) - TP322502 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

DAP12 Recombinant Protein Antigen - NBP1-85313PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TYROBP Protein Lysate - orb333406 from Biorbyt Category Protein Prices $400.00 Sizes 200 μg Species Human

TYROBP Peptide, Human - M34GP16915H from Creative Peptides Category Peptide Source Synthetic. Species Human

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