Gene Symbol | GRM5 |
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Entrez Gene | 2915 |
Alt Symbol | GPRC1E, MGLUR5, PPP1R86, mGlu5 |
Species | Human |
Gene Type | protein-coding |
Description | glutamate receptor, metabotropic 5 |
Other Description | metabotropic glutamate receptor 5|protein phosphatase 1, regulatory subunit 86 |
Swissprots | Q6J164 P41594 |
Accessions | EAW59358 EAW59359 P41594 AF052171 AK291362 BAF84051 AW297388 AY608336 AAT37960 BC031602 BC047497 BX282658 CR627311 D28538 BAA05891 D28539 BAA05892 DA316590 DR002861 FJ588505 ACU31022 FJ588506 ACU31023 FJ588507 ACU31024 FJ668670 ACV89822 S64316 AAD13954 U79242 XM_006718828 XP_006718891 XM_011542792 XP_011541094 XM_011542793 XP_011541095 XM_011542794 XP_011541096 XM_011542795 XP_011541097 NM_000842 NP_000833 NM_001143831 NP_001137303 |
Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. {ECO:0000269|PubMed:7908515, ECO:0000269|Ref.7}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:7908515, ECO:0000269|Ref.7}; Multi-pass membrane protein {ECO:0000269|PubMed:7908515, ECO:0000269|Ref.7}. |
Top Pathways | Gap junction, Long-term potentiation, Huntington's disease, Calcium signaling pathway, Glutamatergic synapse |
Metabotropic glutamate receptor 5 (GRM5), Human, ELISA Kit - E01M0097 from ARP American Research Products
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Metabotropic glutamate receptor 5, GRM5, Human, ELISA Kit - E14972h from ARP American Research Products
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Human GRM5 / MGLUR5 ELISA Kit (Sandwich ELISA) - LS-F17564 from LifeSpan Bioscience
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Rat GRM5 / MGLUR5 ELISA Kit (Sandwich ELISA) - LS-F17565 from LifeSpan Bioscience
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Mouse GRM5 / MGLUR5 ELISA Kit (Sandwich ELISA) - LS-F13209 from LifeSpan Bioscience
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Human GRM5 ELISA Kit - E024217 from Biobool
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GRM5 ELISA Kit (Human) (OKEH05453) - OKEH05453 from Aviva Systems Biology
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anti-Metabotropic Glutamate Receptor 5/1a antibody - ARG52339 from Arigo Biolaboratories
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anti-mGluR5 antibody - ARG53290 from Arigo Biolaboratories
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anti-mGluR5 antibody (Ready-to-Use) - ARG53291 from Arigo Biolaboratories
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Metabotropic glutamate receptor 5, ELISA Kit - MBS2884595 from MyBioSource
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Mouse GRM5 / MGLUR5 ELISA Kit (Sandwich ELISA) - LS-F33188 from LifeSpan Bioscience
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