| Gene Symbol |
GRM5
|
| Entrez Gene |
2915
|
| Alt Symbol |
GPRC1E, MGLUR5, PPP1R86, mGlu5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glutamate receptor, metabotropic 5
|
| Other Description |
metabotropic glutamate receptor 5|protein phosphatase 1, regulatory subunit 86
|
| Swissprots |
Q6J164 P41594
|
| Accessions |
EAW59358 EAW59359 P41594 AF052171 AK291362 BAF84051 AW297388 AY608336 AAT37960 BC031602 BC047497 BX282658 CR627311 D28538 BAA05891 D28539 BAA05892 DA316590 DR002861 FJ588505 ACU31022 FJ588506 ACU31023 FJ588507 ACU31024 FJ668670 ACV89822 S64316 AAD13954 U79242 XM_006718828 XP_006718891 XM_011542792 XP_011541094 XM_011542793 XP_011541095 XM_011542794 XP_011541096 XM_011542795 XP_011541097 NM_000842 NP_000833 NM_001143831 NP_001137303
|
| Function |
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. {ECO:0000269|PubMed:7908515, ECO:0000269|Ref.7}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:7908515, ECO:0000269|Ref.7}; Multi-pass membrane protein {ECO:0000269|PubMed:7908515, ECO:0000269|Ref.7}.
|
| Top Pathways |
Gap junction, Long-term potentiation, Huntington's disease, Calcium signaling pathway, Glutamatergic synapse
|